U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 12:18:32 GMT 2023
Edited
by admin
on Sat Dec 16 12:18:32 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
39G0G4XQ32
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA
Common Name English
MED
Common Name English
VOLTAGE-GATED SODIUM CHANNEL SUBUNIT ALPHA NAV1.6
Common Name English
SODIUM CHANNEL PROTEIN TYPE VIII SUBUNIT ALPHA
Common Name English
Code System Code Type Description
FDA UNII
39G0G4XQ32
Created by admin on Sat Dec 16 12:18:32 GMT 2023 , Edited by admin on Sat Dec 16 12:18:32 GMT 2023
PRIMARY
WIKIPEDIA
SCN8A
Created by admin on Sat Dec 16 12:18:32 GMT 2023 , Edited by admin on Sat Dec 16 12:18:32 GMT 2023
PRIMARY
UNIPROT
Q9UQD0
Created by admin on Sat Dec 16 12:18:32 GMT 2023 , Edited by admin on Sat Dec 16 12:18:32 GMT 2023
PRIMARY
PHAROS
Q9UQD0
Created by admin on Sat Dec 16 12:18:32 GMT 2023 , Edited by admin on Sat Dec 16 12:18:32 GMT 2023
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_215
N 1_289
N 1_295
N 1_308
N 1_326
N 1_1358
N 1_1372
N 1_1383
Related Record Type Details
INHIBITOR -> TARGET
Remarkably selective for the NaV1.6 sodium channel over other isoforms (IC50 = 51 nM, 756x vs. NaV1.1, 134X vs. NaV1.2, 276X vs. NaV1.7, >583X vs. 1.3, 1.4, 1.5.
INHIBITOR -> TARGET
Binds to inactivated state and prevents activation
INHIBITOR -> TARGET
EC50
INHIBITOR RESISTANT -> TARGET
NaV1.5, NaV1.8, and NaV1.9 are tetrodotoxin-resistant to varying degrees
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL