Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:18:32 UTC 2023
by
admin
on
Sat Dec 16 12:18:32 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
39G0G4XQ32
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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39G0G4XQ32
Created by
admin on Sat Dec 16 12:18:32 UTC 2023 , Edited by admin on Sat Dec 16 12:18:32 UTC 2023
|
PRIMARY | |||
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SCN8A
Created by
admin on Sat Dec 16 12:18:32 UTC 2023 , Edited by admin on Sat Dec 16 12:18:32 UTC 2023
|
PRIMARY | |||
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Q9UQD0
Created by
admin on Sat Dec 16 12:18:32 UTC 2023 , Edited by admin on Sat Dec 16 12:18:32 UTC 2023
|
PRIMARY | |||
|
Q9UQD0
Created by
admin on Sat Dec 16 12:18:32 UTC 2023 , Edited by admin on Sat Dec 16 12:18:32 UTC 2023
|
PRIMARY |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_215 |
| N | 1_289 |
| N | 1_295 |
| N | 1_308 |
| N | 1_326 |
| N | 1_1358 |
| N | 1_1372 |
| N | 1_1383 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
INHIBITOR -> TARGET |
Remarkably selective for the NaV1.6 sodium channel over other isoforms (IC50 = 51 nM, 756x vs. NaV1.1, 134X vs. NaV1.2, 276X vs. NaV1.7, >583X vs. 1.3, 1.4, 1.5.
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|
INHIBITOR -> TARGET |
Binds to inactivated state and prevents activation
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INHIBITOR -> TARGET |
EC50
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INHIBITOR RESISTANT -> TARGET |
NaV1.5, NaV1.8, and NaV1.9 are tetrodotoxin-resistant to varying degrees
|
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|