Approval Year
Substance Class |
Nucleic Acid
Created
by
admin
on
Edited
Sat Dec 16 19:11:03 GMT 2023
by
admin
on
Sat Dec 16 19:11:03 GMT 2023
|
Nucleic Acid Type | siRNA |
Nucleic Acid Subtype | |
Sequence Origin | SYNTHETIC |
Sequence Type | COMPLETE |
Record UNII |
39CFL75KXH
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
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Official Name | English | ||
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Common Name | English | ||
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Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
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39CFL75KXH
Created by
admin on Sat Dec 16 19:11:03 GMT 2023 , Edited by admin on Sat Dec 16 19:11:03 GMT 2023
|
PRIMARY | |||
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12750
Created by
admin on Sat Dec 16 19:11:03 GMT 2023 , Edited by admin on Sat Dec 16 19:11:03 GMT 2023
|
PRIMARY | |||
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2572991-83-2
Created by
admin on Sat Dec 16 19:11:03 GMT 2023 , Edited by admin on Sat Dec 16 19:11:03 GMT 2023
|
PRIMARY |
Sugar | Site Range | Site Count |
---|---|---|
Deoxyribose (DNA) | 1_12;1_16;2_9;2_11 | 4 / 44 |
2'-O-Methyl-Ribose | 1_1;1_3-1_11;1_13;1_15;1_17-1_23;2_1-2_8;2_10;2_12-2_21 | 38 / 44 |
2'-Fluoro-Ribose | 1_2;1_14 | 2 / 44 |
Linkage | Site Range | Site Count |
---|---|---|
Phosporothioate | 1_2-1_3;1_22-1_23;2_2-2_3;2_20-2_21 | 8 / 42 |
Phosphate | 1_4-1_21;2_4-2_19 | 34 / 42 |
Related Record | Type | Details | ||
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TARGET->INHIBITOR OF EXPRESSION |
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
ALN-APP is a small interfering RNA (siRNA) that targets amyloid precursor protein (APP) messenger RNA (mRNA) resulting in APP synthesis inhibition
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Structural Modifications
Modification Type | Location Site | Location Type | Residue Modified | Extent | Fragment Name | Fragment Approval |
---|---|---|---|---|---|---|
NUCLEOSIDE_SUBSTITUTION | [2_6] | SITE_SPECIFIC | UNSPECIFIED SUBSTANCE |
4dcb2604
(not in database)
|
||
NUCLEOTIDE SUBSTITUTION | [1_7] | SITE_SPECIFIC | 1-((2S)-1-(2,3-DIHYDROXY)PROPYL)THYMINE-PHOSPHATE | 3BH2CF5QM5 | ||
NUCLEOTIDE SUBSTITUTION | [1_1] | SITE_SPECIFIC | UNSPECIFIED SUBSTANCE |
e70ce8ff
(not in database)
|