Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H7N5O |
| Molecular Weight | 165.1527 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1C=NC2=C1N=C(N)NC2=O
InChI
InChIKey=UUWJNBOCAPUTBK-UHFFFAOYSA-N
InChI=1S/C6H7N5O/c1-11-2-8-3-4(11)9-6(7)10-5(3)12/h2H,1H3,(H3,7,9,10,12)
| Molecular Formula | C6H7N5O |
| Molecular Weight | 165.1527 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Chemotherapy and targeted treatments in glioblastomas]. | 2010-12 |
|
| Microhydration of the guanine-guanine and guanine-cytosine base pairs. | 2010-10-28 |
|
| Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco-specific nitrosamines. | 2010-09-05 |
|
| O6-methylguanine-DNA methyltransferase gene coding region polymorphisms and oral cancer risk. | 2010-09 |
|
| Acetaldehyde adducts in alcoholic liver disease. | 2010-08-19 |
|
| Does stacking restrain the photodynamics of individual nucleobases? | 2010-06-23 |
|
| The excited electronic states of adenine-guanine stacked dimers in aqueous solution: a PCM/TD-DFT study. | 2010-05-21 |
|
| Novel riboswitch ligand analogs as selective inhibitors of guanine-related metabolic pathways. | 2010-04-22 |
|
| An ab initio and AIM investigation into the hydration of 2-thioxanthine. | 2010-03-23 |
|
| Microhydration of 9-methylguanine:1-methylcytosine base pair and its radical anion: a density functional theory study. | 2010-02-14 |
|
| Energy barriers between H-bonded and stacked structures of 9-methyladenine...1-methylthymine and 9-methylguanine...1-methylcytosine complexes. | 2010-01-21 |
|
| Interaction of host cellular proteins with components of the hepatitis delta virus. | 2010-01 |
|
| Critical appraisal of temozolomide formulations in the treatment of primary brain tumors: patient considerations. | 2009-10-30 |
|
| Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. | 2009-10 |
|
| Stool methylation-specific polymerase chain reaction assay for the detection of colorectal neoplasia in Korean patients. | 2009-08 |
|
| Expanding the pH range of metal-nucleobase complexes for acid-base chemistry: properties of bis(guanine) complexes of (bpy)Pt(II) with either two major or major and minor tautomers bonded simultaneously. | 2009-06-15 |
|
| Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. | 2009-05 |
|
| IR-UV double resonance spectroscopy of the hydrated clusters of guanosine and 9-methylguanine: evidence for hydration structures involving the sugar group. | 2009-04-16 |
|
| Valence anions of 9-methylguanine-1-methylcytosine complexes. Computational and photoelectron spectroscopy studies. | 2009-02-25 |
|
| Genome analysis and genome-wide proteomics of Thermococcus gammatolerans, the most radioresistant organism known amongst the Archaea. | 2009 |
|
| Role of the phosphine ligands on the stabilization of monoadducts of the model nucleobases 1-methylcytosine and 9-methylguanine in platinum(II) complexes. | 2008-04-07 |
|
| Prognostic significance of DNA repair proteins MLH1, MSH2 and MGMT expression in non-small-cell lung cancer and precursor lesions. | 2008-04 |
|
| Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. | 2008-03 |
|
| DNA methylation in circulating tumour DNA as a biomarker for cancer. | 2008-01-25 |
|
| Incorporating molecular tools into early-stage clinical trials. | 2008-01-22 |
|
| Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East. | 2007-12 |
|
| Rates of spontaneous disintegration of DNA and the rate enhancements produced by DNA glycosylases and deaminases. | 2007-11-27 |
|
| Dual mechanisms of DNA damage by MoCH(3)(eta(3)-allyl)(CO)(2)(phen) complexes. | 2007-11-09 |
|
| Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds. | 2007-09-07 |
|
| Canadian recommendations for the treatment of glioblastoma multiforme. | 2007-06 |
|
| Interguanine hydrogen-bonding patterns in adducts with water and Zn-purine complexes (purine is 9-methyladenine and 9-methylguanine). Unexpected preference of Zn(II) for adenine-N7 over guanine-N7. | 2007-05 |
|
| Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications. | 2007-04-02 |
|
| Targeted brain tumor treatment-current perspectives. | 2007 |
|
| A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase. | 2006-09 |
|
| Theoretical study of the ground and excited states of 7-methyl guanine and 9-methyl guanine: comparison with experiment. | 2006-07-14 |
|
| Poxvirus mRNA cap methyltransferase. Bypass of the requirement for the stimulatory subunit by mutations in the catalytic subunit and evidence for intersubunit allostery. | 2006-07-14 |
|
| Methylguanine DNA methyl transferase activities, glutathione s transferase and nitric oxide in bladder cancer patients. | 2006-07-01 |
|
| hMLH1 and MGMT inactivation as a mechanism of tumorigenesis in monoclonal gammopathies. | 2006-07 |
|
| [Effect of carboxylate and Na ions on the tautomeric status of 9-methylguanine]. | 2005-08-17 |
|
| Cyanide-bridged vitamin B12-cisplatin conjugates. | 2005-07-04 |
|
| [New place of the chemotherapy in gliomas]. | 2005-04 |
|
| Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. | 2005-01 |
|
| Prereplicative purine methylation and postreplicative demethylation in each DNA duplication of the Escherichia coli replication cycle. | 2004-12-03 |
|
| Binding of 9-methylguanine to [cis-Ru(2,2'-bpy)2]2+: First X-ray structure of a cis-bis purine complex of ruthenium. | 2004-05-03 |
|
| Head-to-head (HH) and head-to-tail (HT) conformers of cis-bis guanine ligands bound to the [Re(CO)3]+ core. | 2004-03-22 |
|
| Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells. | 2004-02-01 |
|
| Colorectal carcinogenesis: MSI-H versus MSI-L. | 2004 |
|
| True stabilization energies for the optimal planar hydrogen-bonded and stacked structures of guanine...cytosine, adenine...thymine, and their 9- and 1-methyl derivatives: complete basis set calculations at the MP2 and CCSD(T) levels and comparison with experiment. | 2003-12-17 |
|
| Theoretical study of substitution effect of the hydrogen bond stability of 9-methylguanine derivatives and 1-methylcytosine. | 2002 |
|
| Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. | 1995-11-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:05:27 GMT 2025
by
admin
on
Mon Mar 31 21:05:27 GMT 2025
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| Record UNII |
397W61ZHWY
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| Record Status |
Validated (UNII)
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| Record Version |
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