Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H3NS |
| Molecular Weight | 85.128 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
S1C=CC=N1
InChI
InChIKey=ZLTPDFXIESTBQG-UHFFFAOYSA-N
InChI=1S/C3H3NS/c1-2-4-5-3-1/h1-3H
| Molecular Formula | C3H3NS |
| Molecular Weight | 85.128 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery. | 2010-11-15 |
|
| In silico exploration for identifying structure-activity relationship of MEK inhibition and oral bioavailability for isothiazole derivatives. | 2010-11 |
|
| Ligand-exchange processes on solvated zinc cations: water exchange on [Zn(H2O)4(L)]2+.2H2O (L=heterocyclic ligand). | 2010-06-25 |
|
| Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays. | 2010-05 |
|
| Synthesis and immunomodulatory activites of new 5-hydrazino-3-methyl-4-isothiazolecarboxylic acid ethyl esters. | 2009-11-10 |
|
| Synthesis and pharmacological evaluation of thiazole and isothiazole derived apomorphines. | 2009-10 |
|
| Synthesis of novel vanillin derivatives containing isothiazole moieties and its synergistic effect in mixtures with insecticides. | 2009-09 |
|
| New amides of 5-(4-chlorobenzoyl)aminoorotic acid: their synthesis and biological activity. | 2008-11 |
|
| Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors. | 2008-08-15 |
|
| New derivatives of 5-amino-3-methyl-4-isothiazolecarboxylic acid and their immunological activity. | 2007-08-19 |
|
| Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid. | 2007-02-07 |
|
| Isothiazole derivatives as antiviral agents. | 2007 |
|
| New regiospecific isothiazole C-C coupling chemistry. | 2006-10-07 |
|
| Discovery of novel isothiazole inhibitors of the TrkA kinase: structure-activity relationship, computer modeling, optimization, and identification of highly potent antagonists. | 2006-07-01 |
|
| New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity. | 2006-07 |
|
| Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation. | 2005-12-05 |
|
| Isothiazole derivatives as novel HIV replication inhibitors. | 2004-07 |
|
| Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors. | 2004-02-23 |
|
| Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. | 2003-11-01 |
|
| Regiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrile. | 2003-08-21 |
|
| Novel synthesis and reactions of 5,7-dialkyl-4,6-dioxo-4,5,6,7-tetrahydro- isothiazolo[3,4,-d]pyrimidine-3-carbonitriles and 6-methyl-4-oxo-4H-1-aza-5-oxa-2- thiaindene-3-carbonitrile. | 2003-02-20 |
|
| [Biological activity of the isothiazole derivatives]. | 2003 |
|
| [Synthesis and monolayer behaviors of 4-methyl-5-hydroxy-ethyl isothiazole stearic ester]. | 2002-12 |
|
| Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase. | 2002-08-19 |
|
| Synthesis of new 3-methylthio-5-aryl-4-isothiazolecarbonitriles with broad antiviral spectrum. | 2002-08 |
|
| Efficient synthesis of fused isothiazolo C-nucleosides. III. Synthesis of substituted isothiazol. | 2001-03 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:51:13 GMT 2025
by
admin
on
Mon Mar 31 19:51:13 GMT 2025
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| Record UNII |
38FAO14250
|
| Record Status |
Validated (UNII)
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| Record Version |
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67515
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38FAO14250
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1495075
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DTXSID90182980
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ISOTHIAZOLE
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