TRYPARSAMIDE HEMIHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C8H10AsN2O4.2Na.H2O
Molecular Weight	610.19
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.[Na+].[Na+].NC(=O)CNC1=CC=C(C=C1)[As](O)([O-])=O.NC(=O)CNC2=CC=C(C=C2)[As](O)([O-])=O

InChI

InChIKey=CGSBXNNKDCWLRS-UHFFFAOYSA-L

InChI=1S/2C8H11AsN2O4.2Na.H2O/c2*10-8(12)5-11-7-3-1-6(2-4-7)9(13,14)15;;;/h2*1-4,11H,5H2,(H2,10,12)(H2,13,14,15);;;1H2/q;;2*+1;/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C8H10AsN2O4
Molecular Weight	273.0976
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=NCI_Thesaurus&code=C66646 | https://jamanetwork.com/journals/jama/article-abstract/231666 | https://www.ncbi.nlm.nih.gov/pubmed/20315250

Tryparsamide is an arsenic compound with activity against Spirochaetes bacteria. Tryparsamide is used in the treatment of syphilis and African sleeping sickness. For decades Tryparsamide remained the standard treatment for trypanosomiasis. Tryparsamide has two remarkable properties: first, it increases the resistance of the individual by improving his general physical status; and, second, the high penetrability for nervous tissue which it possesses may increase the potential spirocheticidal action of the drug.

CNS Activity

Originator

Approval Year

PubMed

Title	Date	PubMed
Tryparsamide Therapy of Neurosyphilis in Negroes.	1931 Jul	20892469
General Discussion on Tryparsamide and Stovarsol: Meeting of The Medical Society for the Study of Venereal Diseases. London. July 13th, 1940.	1941 Jan	21773307
The present status of tryparsamide in syphilotherapy.	1947 May	20238904

Sample Use Guides

In Vivo Use Guide

The proper dosage for the average individual is to 3 grams of the drug. This amount dissolved in 10-20 cc. of sterile distilled water is given weekly. It may be given subcutaneously, intramuscularly or intravenously. The intravenous route is the preferable one to use. It should be given slowly by the syringe method.

Route of Administration: Parenteral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:36:25 GMT 2023` Edited by `admin` on `Sat Dec 16 09:36:25 GMT 2023`
Record UNII	38892Q01QB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRYPARSAMIDE HEMIHYDRATE

Common Name

English

ARSONIC ACID, (4-((2-AMINO-2-OXOETHYL)AMINO)PHENYL)-, MONOSODIUM SALT, HYDRATE (2:1)

Systematic Name

English

AS-(4-((2-AMINO-2-OXOETHYL)AMINO)PHENYL)ARSONIC ACID SODIUM SALT (1:1), HEMIHYDRATE

Systematic Name

English

TRYPARSAMIDE 0.5 HYDRATE

Common Name

English

TRYPARSAMIDE HEMIHYDRATE [MI]

Common Name

English

Code System Code Type Description

CAS

6159-29-1