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Details

Stereochemistry ACHIRAL
Molecular Formula C4H11NO3.ClH
Molecular Weight 157.5961
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TROMETHAMINE HYDROCHLORIDE

SMILES

C(C(CO)(CO)N)O.Cl

InChI

InChIKey=QKNYBSVHEMOAJP-UHFFFAOYSA-N
InChI=1S/C4H11NO3.ClH/c5-4(1-6,2-7)3-8;/h6-8H,1-3,5H2;1H

HIDE SMILES / InChI

Molecular Formula C4H11NO3
Molecular Weight 121.1352
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula ClH
Molecular Weight 36.4609
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: http://www.cir-safety.org/sites/default/files/Tromet_092013_Rep.pdf

be used to maintain the pH of body fluids. Tromethamine is indicated for the prevention and correction of metabolic acidosis. When administered intravenously as a 0.3 M solution, tromethamine acts as a proton acceptor and prevents or corrects acidosis by actively binding hydrogen ions (H+). It binds not only cations of fixed or metabolic acids, but also hydrogen ions of carbonic acid, thus increasing bicarbonate anion (HCO3‾). TromeThamine also acts as an osmotic diuretic, increasing urine flow, urinary pH, and excretion of fixed acids, carbon dioxide and electrolytes. A significant fraction of tromethamine (30% at pH 7.40) is not ionized and therefore is capable of reaching equilibrium in total body water. This portion may penetrate cells and may neutralize acidic ions of the intracellular fluid.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Tham

Approved Use

indicated for the prevention and correction of metabolic acidosis. In the following conditions it may help to sustain vital functions and thus provide time for treatment of the primary disease: Metabolic Acidosis Associated with Cardiac Bypass Surgery. Tham Solution has been found to be primarily beneficial in correcting metabolic acidosis which may occur during or immediately following cardiac bypass surgical procedures. Correction of Acidity of ACD Blood in Cardiac Bypass Surgery. It is well known that ACD blood is acidic and becomes more acidic on storage. TromeThamine effectively corrects this acidity. Tham Solution may be added directly to the blood used to prime the pump-oxygenator. When ACD blood is brought to a normal pH range the patient is spared an initial acid load. Additional tromeThamine may be indicated during cardiac bypass surgery should metabolic acidosis appear. Metabolic Acidosis Associated with Cardiac Arrest.

Launch Date

-127699200000
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL.
2001
Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice.
2001
Cell adhesion and signaling on the fibronectin 1st type III repeat; requisite roles for cell surface proteoglycans and integrins.
2001
Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons.
2001
The antioxidant activity of BHT and new phenolic compounds PYA and PPA measured by chemiluminescence.
2001
MP20, the second most abundant lens membrane protein and member of the tetraspanin superfamily, joins the list of ligands of galectin-3.
2001
Early events in the polymerization of fibrin.
2001
Pathological apoptosis by xanthurenic acid, a tryptophan metabolite: activation of cell caspases but not cytoskeleton breakdown.
2001
Effect of biofluid environment on the dissolution and flexural strength of calcium phosphate bone cements.
2001
Early-morning administration of dexketoprofen-trometamol in morning stiffness induced by nodal osteoarthritis of the hands.
2001
Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in Bacillus subtilis.
2001
Site-specific mutations of FtsZ--effects on GTPase and in vitro assembly.
2001
Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling.
2001
Determination of cyclodextrins and their derivatives by capillary electrophoresis with indirect UV and conductivity detection.
2001 Apr
Thermolysis of free-radical initiators: tert-butylazocumene and its 1,3- and 1,4-bisazo and 1,3,5-trisazo analogues.
2001 Apr 25
Evidence for specific ceramidase present in the intestinal contents of rats and humans.
2001 Aug
Formaldehyde production by Tris buffer in peptide formulations at elevated temperature.
2001 Aug
Comparison of ketorolac tromethamine 0.5% and rimexolone 1% to control inflammation after cataract extraction. Prospective randomized double-masked study.
2001 Aug
Analysis of vancomycin and related impurities by micellar electrokinetic capillary chromatography. Method development and validation.
2001 Aug
Lipopolysaccharide stimulates norepinephrine efflux from the rat hypothalamus in vitro: blockade by soluble IL-1 receptor.
2001 Aug 3
Sintering temperature effects on the in vitro bioactive response of tape cast and sintered bioactive glass-ceramic in Tris buffer.
2001 Dec 15
Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine.
2001 Jan-Feb
Analysis of glutathione by capillary electrophoresis based on sample stacking.
2001 Jul
Basic fibroblast growth factor inhibits choriocapillaris atrophy in rabbit.
2001 Jul
Recognition and strand displacement of DNA oligonucleotides by peptide nucleic acids (PNAs). High-performance ion-exchange chromatographic analysis.
2001 Jul 13
Thiols prevent H2O2-mediated loss of sperm motility in cryopreserved bull semen.
2001 Jul 15
Phosphodiester hydrolysis by lanthanide complexes of bis-tris propane.
2001 Jul 16
Topical ketorolac tromethamine in the reduction of adverse effects of laser in situ keratomileusist.
2001 Jun
Feasibility of urinary trans, trans-muconic acid determination using high performance liquid chromatography for biological monitoring of benzene exposure.
2001 Jun
Thin-layer chromatographic behavior of rare earths on silica gel with aqueous alkaline earth metal nitrate solutions as mobile phases.
2001 Jun
Recognition of 16S rRNA by ribosomal protein S4 from Bacillus stearothermophilus.
2001 Jun 19
Short-chain fatty acids enhance diffusional ca transport in the epithelium of the rat cecum and colon.
2001 Jun 22
Behaviour of inorganic and organic cations in the Debye-Hückel layer of DNA.
2001 Jun 22
Agonist-stimulated [35S]GTPgammaS autoradiography: optimization for high sensitivity.
2001 Jun 22
Influence of bulky N-substituents on the formation of lanthanide triple helical complexes with a ligand derived from bis(benzimidazole)pyridine: structural and thermodynamic evidence.
2001 Jun 4
Inhibition of human CYP1A2 activity in vitro by methylxanthines: potent competitive inhibition by 8-phenyltheophylline.
2001 Mar
Preparation and compressive strength of alpha-tricalcium phosphate/gelatin gel composite cement.
2001 Mar 15
HCO3- potentiates the cAMP-dependent secretory response of the human distal colon through a DIDS-sensitive pathway.
2001 May
Contact allergy to trometamol.
2001 May
Therapy of malignant intracranial hypertension by controlled lumbar cerebrospinal fluid drainage.
2001 May
Stereospecificity of myo-inositol hexakisphosphate dephosphorylation by a phytate-degrading enzyme of baker's yeast.
2001 May
Maltodextrin-anionic surfactant interactions: isothermal titration calorimetry and surface tension study.
2001 Oct
Characterization of a 5'-aldehyde terminus resulting from the oxidative attack at C5' of a 2-deoxyribose on DNA.
2001 Oct
A prospective randomised trial to compare the efficacy and safety of hemabate and syntometrine for the prevention of primary postpartum haemorrhage.
2001 Oct
Use of base in the treatment of severe acidemic states.
2001 Oct
Electrophysiological and biochemical changes in rabbit hearts stored at 4 degrees C for 6 or 24 h.
2001 Oct
Generation of live rat offspring by intrauterine insemination with epididymal spermatozoa cryopreserved at -196 degrees C.
2001 Sep
Detergent-like action of the antibiotic peptide surfactin on lipid membranes.
2001 Sep
Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle.
2001 Sep 15
Design, formation and properties of tetrahedral M(4)L(4) and M(4)L(6) supramolecular clusters.
2001 Sep 19
Patents

Patents

Sample Use Guides

Usual Adult Dose for Metabolic Acidosis
Route of Administration: Intravenous
25-100 mM Tris (Tromethamine) completely inhibits starch-synthase
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:56:55 UTC 2021
Edited
by admin
on Sat Jun 26 04:56:55 UTC 2021
Record UNII
383V75M34E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TROMETHAMINE HYDROCHLORIDE
Common Name English
TRIS HYDROCHLORIDE
Common Name English
TRIS-HCL
Common Name English
2-AMINO-2-(HYDROXYMETHYL)PROPANE-1,3-DIOL HYDROCHLORIDE
Systematic Name English
TROMETAMOL HYDROCHLORIDE
WHO-DD  
Common Name English
TRIZMA HYDROCHLORIDE
Common Name English
TROMETAMOL HYDROCHLORIDE [WHO-DD]
Common Name English
TROMETHAMINE HCL
Common Name English
Code System Code Type Description
CAS
1185-53-1
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
RXCUI
1311534
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY RxNorm
FDA UNII
383V75M34E
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
ECHA (EC/EINECS)
214-684-5
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
EVMPD
SUB39625
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
PUBCHEM
93573
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
EPA CompTox
1185-53-1
Created by admin on Sat Jun 26 04:56:55 UTC 2021 , Edited by admin on Sat Jun 26 04:56:55 UTC 2021
PRIMARY
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PARENT -> SALT/SOLVATE
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ACTIVE MOIETY