TICABESONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H28F2O4S
Molecular Weight	426.517
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CSC(=O)[C@@]1(O)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

InChI

InChIKey=TYVHQHCXWZVELU-GQKYHHCASA-N

InChI=1S/C22H28F2O4S/c1-11-7-13-14-9-16(23)15-8-12(25)5-6-19(15,2)21(14,24)17(26)10-20(13,3)22(11,28)18(27)29-4/h5-6,8,11,13-14,16-17,26,28H,7,9-10H2,1-4H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C22H28F2O4S
Molecular Weight	426.517
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	9 / 9
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22000935

Ticabesone is a thioetianic acid derivative patented by Syntex, Inc. as anti-inflammatory agent. The topical antiinflammatory activity of Ticabesone was assessed in humans by vasoconstriction assay.

Originator

Approval Year

PubMed

Title	Date	PubMed
Drug effects on the neovascularization response to silver nitrate cauterization of the rat cornea.	1985-05	2410194

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:00:26 GMT 2025` Edited by `admin` on `Mon Mar 31 19:00:26 GMT 2025`
Record UNII	3805C1ABKY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ticabesone [INN]

Preferred Name

English

TICABESONE

Official Name

English

S-METHYL 6.ALPHA.,9-DIFLUORO-11.BETA.,17-DIHYDROXY-16.ALPHA.-METHYL-3-OXOANDROSTA-1,4-DIENE-17.BETA.-CARBOTHIOATE

Common Name

English

ANDROSTA-1,4-DIENE-17-CARBOTHIOIC ACID, 6,9-DIFLUORO-11,17-DIHYDROXY-16-METHYL-3-OXO-, S-METHYL ESTER, (6.ALPHA.,11.BETA.,16.ALPHA.,17.ALPHA.)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521