ZILGANERSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 17:32:12 GMT 2023` Edited by `admin` on `Sat Dec 16 17:32:12 GMT 2023`
Nucleic Acid Type	MRNA
Nucleic Acid Subtype	ANTI-SENSE
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	37YVE86ZYS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ZILGANERSEN SODIUM

Official Name

English

DNA, D((2'-O-(2-METHOXYETHYL))M5RC-SP-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))RA-(2'-O-(2-METHOXYETHYL))M5RU-T-SP-A-SP-M5C-SP-M5C-SP-T-SP-M5C-SP-T-SP-A-SP-M5C-SP-T-SP-(2'-O-(2-METHOXYETHYL))R

Common Name

English

ZILGANERSEN SODIUM [USAN]

Common Name

English

ION-1166998

Code

English

Code System Code Type Description

CAS

2305355-64-8

Created by admin on Sat Dec 16 17:32:12 GMT 2023 , Edited by admin on Sat Dec 16 17:32:12 GMT 2023

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FDA UNII

37YVE86ZYS

Created by admin on Sat Dec 16 17:32:12 GMT 2023 , Edited by admin on Sat Dec 16 17:32:12 GMT 2023

PRIMARY

USAN

HI-43

Created by admin on Sat Dec 16 17:32:12 GMT 2023 , Edited by admin on Sat Dec 16 17:32:12 GMT 2023

PRIMARY

NCI_THESAURUS

C186385

Created by admin on Sat Dec 16 17:32:12 GMT 2023 , Edited by admin on Sat Dec 16 17:32:12 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methoxyethyl ribose	1_1-1_6;1_17-1_20	10 / 20
Deoxyribose (DNA)	1_7-1_16	10 / 20

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2;1_8-1_17;1_19-1_20	13 / 19
	1_3-1_7;1_18	6 / 19

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ZILGANERSEN

PARENT -> SALT/SOLVATE

Amount:

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ZILGANERSEN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_1] [1_9] [1_10] [1_12] [1_15] [1_20]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE BASE SUBSTITUTION	[1_4] [1_6]	SITE_SPECIFIC			THYMINE	QR26YLT7LT