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Details

Stereochemistry ACHIRAL
Molecular Formula C8H15NO2
Molecular Weight 157.2102
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TRANEXAMIC ACID, CIS-

SMILES

NC[C@H]1CC[C@H](CC1)C(O)=O

InChI

InChIKey=GYDJEQRTZSCIOI-KNVOCYPGSA-N
InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7+

HIDE SMILES / InChI

Molecular Formula C8H15NO2
Molecular Weight 157.2102
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

cis-Tranexamic acid blocks the plasminogen, and thus possesses antifibrinolytic properties.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P00747
Gene ID: 5340.0
Gene Symbol: PLG
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Effects of tranexamic acid, cis-AMCHA, and 6-aminohexanoic acid on the activation rate of plasminogen by urokinase in the presence of clot.
1979
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
When human plasma was mixed with 50 units of urokinase and clotted with thrombin in the presence of S-2251, the hydrolysis of S-2251 in the clot was higher than that in the plasma. The addition of 6-aminohexanoic acid or cis-AMCHA (cis-Tranexamic Acid) showed changes in the rate of plasminogen activation similar to that shown in the presence of tranexamic acid. 1 mM of cis-AMCHA and 6-aminohexanoic acid totally inhibited clot lysis. The presence of 1 mM of these ω-aminoacids remarkably increased the activation of plasminogen by urokinase, but no clot lysis was observed.
Substance Class Chemical
Created
by admin
on Sat Dec 16 09:16:33 GMT 2023
Edited
by admin
on Sat Dec 16 09:16:33 GMT 2023
Record UNII
37YD696II6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TRANEXAMIC ACID, CIS-
Common Name English
TRANEXAMIC ACID RELATED COMPOUND B [USP IMPURITY]
Common Name English
CIS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID
Systematic Name English
CIS-AMCHA
Common Name English
CIS-TRANEXAMIC ACID
Common Name English
TRANEXAMIC ACID RELATED COMPOUND B
USP  
Common Name English
TRANEXAMIC ACID CIS-FORM [MI]
Common Name English
TRANEXAMIC ACID IMPURITY B [EP IMPURITY]
Common Name English
CYCLOHEXANECARBOXYLIC ACID, 4-(AMINOMETHYL)-, CIS-
Systematic Name English
Code System Code Type Description
PUBCHEM
5526
Created by admin on Sat Dec 16 09:16:33 GMT 2023 , Edited by admin on Sat Dec 16 09:16:33 GMT 2023
PRIMARY
MERCK INDEX
m11000
Created by admin on Sat Dec 16 09:16:33 GMT 2023 , Edited by admin on Sat Dec 16 09:16:33 GMT 2023
PRIMARY Merck Index
CAS
1197-17-7
Created by admin on Sat Dec 16 09:16:33 GMT 2023 , Edited by admin on Sat Dec 16 09:16:33 GMT 2023
PRIMARY
FDA UNII
37YD696II6
Created by admin on Sat Dec 16 09:16:33 GMT 2023 , Edited by admin on Sat Dec 16 09:16:33 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> IMPURITY
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP