Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C3H7N |
| Molecular Weight | 57.0944 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CNC1
InChI
InChIKey=HONIICLYMWZJFZ-UHFFFAOYSA-N
InChI=1S/C3H7N/c1-2-4-3-1/h4H,1-3H2
| Molecular Formula | C3H7N |
| Molecular Weight | 57.0944 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Azetidine derivatives as novel gamma-aminobutyric acid uptake inhibitors: synthesis, biological evaluation, and structure-activity relationship. | 2010-06 |
|
| Targeted mutation of the mouse Grp94 gene disrupts development and perturbs endoplasmic reticulum stress signaling. | 2010-05-26 |
|
| Lithiation-electrophilic substitution of N-thiopivaloylazetidine. | 2010-04-06 |
|
| Synthesis and antimycobacterial activity of azetidine-, quinazoline-, and triazolo-thiadiazole-containing pyrazines. | 2010-04 |
|
| Identification of a urea bioisostere of a triazole oxytocin antagonist. | 2010-03-15 |
|
| An efficient stereoselective synthesis of penaresidin a from (e)-2-protected amino-3,4-unsaturated sulfoxide. | 2010-02-05 |
|
| A theoretical study of dihydrogen bonds in small protonated rings: aziridine and azetidine cations. | 2010-02 |
|
| Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. | 2010-01-19 |
|
| Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance. | 2010-01 |
|
| Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. | 2009-12-10 |
|
| Silver(I)-catalyzed dual activation of propargylic alcohol and aziridine/azetidine: triggering ring-opening and endo-selective ring-closing in a cascade. | 2009-11-20 |
|
| Further evidence for 2-alkyl-2-carboxyazetidines as gamma-turn inducers. | 2009-11-06 |
|
| Structure based design of novel irreversible FAAH inhibitors. | 2009-10-15 |
|
| Striking reactivity of a stable, zwitterionic silylene towards substituted diazomethanes, azides, and isocyanides. | 2009-08-24 |
|
| Preparation of heteroaryloxetanes and heteroarylazetidines by use of a Minisci reaction. | 2009-08-21 |
|
| Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate. | 2009-08-20 |
|
| Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas. | 2009-08-01 |
|
| Chemistry and pharmacology of nicotinic ligands based on 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol (AMOP-H-OH) for possible use in depression. | 2009-08 |
|
| A practical method for targeted library design balancing lead-like properties with diversity. | 2009-05 |
|
| One-carbon ring expansion of azetidines via ammonium ylide [1,2]-shifts: a simple route to substituted pyrrolidines. | 2009-04-03 |
|
| Diastereoselective synthesis of bicyclic gamma-lactams via ring expansion of monocyclic beta-lactams. | 2009-02-20 |
|
| Functionalised azetidines as ligands: species derived by selective alkylation at substituent-nitrogen. | 2009-01-21 |
|
| Functionalised azetidines as ligands: pyridyl-complemented coordination. | 2009-01-21 |
|
| Regioselectivity control in the metal-catalyzed functionalization of gamma-allenols, part 2: Theoretical study. | 2009 |
|
| Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors. | 2009 |
|
| Synthesis of chiral organocatalysts derived from aziridines: application in asymmetric aldol reaction. | 2008-12-05 |
|
| Regio- and stereoselective ring opening of enantiomerically enriched 2-aryl oxetanes and 2-aryl azetidines with aryl borates. | 2008-11-21 |
|
| Cycloreversion of azetidines via oxidative electron transfer. steady-state and time-resolved studies. | 2008-11-20 |
|
| New chemistry of olefin complexes of platinum(II) unravelled by basic conditions: synthesis and properties of elusive cationic species. | 2008-10-21 |
|
| Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo. | 2008-10 |
|
| Azetidine, pyrrolidine and hexamethyleneimine at 170 K. | 2008-10 |
|
| Hsf1 is required for the nuclear translocation of p53 tumor suppressor. | 2008-10 |
|
| Preparation of aryloxetanes and arylazetidines by use of an alkyl-aryl suzuki coupling. | 2008-08-07 |
|
| Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. | 2008-08 |
|
| Spectroscopic characterization of the 1-substituted 3,3-diphenyl-4-(2'-hydroxyphenyl)azetidin-2-ones: application of (13)C NMR, (1)H-(13)C COSY NMR and mass spectroscopy. | 2008-08 |
|
| Novel antibacterial azetidine lincosamides. | 2008-04-15 |
|
| N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents. | 2008-03-15 |
|
| Azetidine-derived amino acids versus proline derivatives. alternative trends in reverse turn induction. | 2008-03-07 |
|
| Synthesis of New Quinolone Antibiotics Utilizing Azetidine Derivatives Obtained from 1-Azabicyclo[1.1.0]butane. | 2008-03 |
|
| Theoretical studies on four-membered ring compounds with NF2, ONO2, N3, and NO2 groups. | 2008-03 |
|
| Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases. | 2008-02-28 |
|
| RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines. | 2008-01-15 |
|
| Evaluation of enantiopure N-(ferrocenylmethyl)azetidin-2-yl(diphenyl)methanol for catalytic asymmetric addition of organozinc reagents to aldehydes. | 2008-01-04 |
|
| Pyrvinium targets the unfolded protein response to hypoglycemia and its anti-tumor activity is enhanced by combination therapy. | 2008 |
|
| Role of biotransformation studies in minimizing metabolism-related liabilities in drug discovery. | 2008 |
|
| Direct organocatalytic synthesis of enantiopure succinimides from beta-lactam aldehydes through ring expansion promoted by azolium salt precatalysts. | 2007-12-07 |
|
| NS-187 (INNO-406), a Bcr-Abl/Lyn dual tyrosine kinase inhibitor. | 2007-11-14 |
|
| Convenient synthesis of trans-beta-amino carboxylic esters with an azetidine skeleton via rearrangement of beta,gamma-aziridino alpha-amino esters. | 2007-10-11 |
|
| A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. | 2007-09-15 |
|
| Synthesis of penaresidin derivatives and its biological activity. | 2007-07-15 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:54:32 GMT 2025
by
admin
on
Mon Mar 31 19:54:32 GMT 2025
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| Record UNII |
37S883XDWR
|
| Record Status |
Validated (UNII)
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| Record Version |
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AZETIDINE
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10422
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503-29-7
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37S883XDWR
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DTXSID8060117
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207-963-8
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30968
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