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Details

Stereochemistry ACHIRAL
Molecular Formula C18H35O2.H4N
Molecular Weight 301.5078
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMMONIUM STEARATE

SMILES

[NH4+].CCCCCCCCCCCCCCCCCC([O-])=O

InChI

InChIKey=JPNZKPRONVOMLL-UHFFFAOYSA-N
InChI=1S/C18H36O2.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;/h2-17H2,1H3,(H,19,20);1H3

HIDE SMILES / InChI

Molecular Formula H3N
Molecular Weight 17.0305
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C18H36O2
Molecular Weight 284.4772
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Stearic Acid is a typical example of a fatty acid, which are essentially long hydrocarbon chains containing a carboxyl group at one end and a methyl group at the other. The chain lengths can vary from 3 (propionic acid) to 24 (lignoceric acid) but the majority of fatty acids found in hydrogenated vegetable or animal oils are around C16-C20 in length. Stearic acid is a saturated acid, since there are no double bonds between neighbouring carbon atoms. Stearic acid is found in various animal and plant fats, and is a major component of cocoa butter and shea butter. Stearic acid is a very common amino acid is used in the manufacturing of more than 3,200 skin and hair care products sold in the United States. On product labels, it is sometimes listed under other names, including Century 1240, cetylacetic acid, Emersol 120, Emersol 132, Emersol 150, Formula 300 and Glycon DP. Stearic Acid is mainly used in the production of detergents, soaps, and cosmetics such as shampoos and shaving cream products. Stearic acid is used along with castor oil for preparing softeners in textile sizing. Being inexpensively available and chemically benign, stearic acid finds many niche applications It is used in the manufacture of candles, and as a hardener in candies when mixed with simple sugar and corn syrup. It is also used to produce dietary supplements. In fireworks, stearic acid is often used to coat metal powders such as aluminum and iron. This prevents oxidation, allowing compositions to be stored for a longer period of time. Stearic acid is a common lubricant during injection molding and pressing of ceramic powders. It is also used as a mold release for foam latex that is baked in stone molds. Stearic acid is known antidiabetic and antioxidant agent.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
9.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
Preventing
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
Preventing
CELLBN First care cleanser

Approved Use

Unknown

Launch Date

1.49575683E12
Preventing
MARY KAY TIMEWISE REPAIR VOLU-FIRM THE GO SET

Approved Use

Uses: helps prevent sunburn if used as directed with other sun protection measures (see Directions), decreases the risk of skin cancer and early skin aging caused by the sun

Launch Date

1.5107904E12
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG



OverviewOther

Other InhibitorOther SubstrateOther Inducer



Drug as perpetrator​
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Characterisation of myogenic cell membrane: II. Dynamic changes in membrane lipids during the differentiation of mouse C2 myoblast cells.
2001
A comparison of reflectance and transmittance near-infrared spectroscopic techniques in determining drug content in intact tablets.
2001
Fatty acid and triglyceride composition of milk fat from lactating Holstein cows in response to supplemental canola oil.
2001 Apr
Biogenic amines in the human neocortex in patients with neocortical and mesial temporal lobe epilepsy: identification with in situ microvoltammetry.
2001 Apr 27
Prediction of drug content and hardness of intact tablets using artificial neural network and near-infrared spectroscopy.
2001 Aug
Heterogeneous fatty acylation of Src family kinases with polyunsaturated fatty acids regulates raft localization and signal transduction.
2001 Aug 17
A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males.
2001 Feb
Effects of lipids and oleic acid on biomass development in anaerobic fixed-bed reactors. Part II: Oleic acid toxicity and biodegradability.
2001 Jan
Long-term stability characterization of a controlled release gastrointestinal therapeutic system coated with a cellulose acetate pseudolatex.
2001 Jan
Discovery of gemifloxacin (Factive, LB20304a): a quinolone of a new generation.
2001 Jan-Feb
Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.
2001 Jul
Isolation and characterization of the human stearoyl-CoA desaturase gene promoter: requirement of a conserved CCAAT cis-element.
2001 Jul 1
DC calcium lactate, a new filler-binder for direct compaction of tablets.
2001 Jun 19
Effect of cholesterol on miscibility and phase behavior in binary mixtures with synthetic ceramide 2 and octadecanoic acid. Infrared studies.
2001 Jun 6
Effect of polymer molecular weight and addition of calcium stearate on response of MG63 osteoblast-like cells to UHMWPE particles.
2001 Mar
[The firmness of Avicel PH 102 and Avicel PH 301 compression and the effect of magnesium stearate] ].
2001 Mar
Formulation and process optimization to eliminate picking from market image tablets.
2001 Mar 14
Effect of magnesium stearate or calcium stearate as additives on dissolution profiles of diltiazem hydrochloride from press-coated tablets with hydroxypropylmethylcellulose acetate succinate in the outer shell.
2001 Mar 23
Saturated non-esterified fatty acids stimulate de novo diacylglycerol synthesis and protein kinase c activity in cultured aortic smooth muscle cells.
2001 May
Characterization of alpha-phase soft proton-exchanged LiNbO3 optical waveguides.
2001 May
On the difficulty of assessing the specific surface area of magnesium stearate.
2001 May 7
Determination of oxamniquine in capsules by HPLC.
2001 Nov
Isofenphos induced metabolic changes in K562 myeloid blast cells.
2001 Oct
Influence of adjuvants on the dissolution profile of tablets containing high doses of spray-dried extract of Maytenus ilicifolia.
2001 Sep
Stress relaxation studies of granules as a function of different lubricants.
2001 Sep
The cytotoxicity and chemical constituents of the hexane fraction of Typhonium flagelliforme (Araceace).
2001 Sep
[Extracellular metabolites of hydrocarbon-oxidizing bacteria as a substrate for sulfate reduction].
2001 Sep-Oct
Response surface methodology to obtain naproxen controlled release tablets from its microspheres with Eudragit L100-55.
2001 Sep-Oct
Food-drug interactions.
2002
Dietary cholesterol modulates delta6 and delta9 desaturase mRNAs and enzymatic activity in rats fed a low-eFA diet.
2002 Apr
Molecular species of acylglycerols incorporating radiolabeled fatty acids from castor (Ricinus communis L.) microsomal incubations.
2002 Aug 28
Studies of rapidly disintegrating tablets in the oral cavity using co-ground mixtures of mannitol with crospovidone.
2002 Feb
Binding of [99mTc]chondroitin sulfate to scavenger receptors on human chondrocytes as compared to binding of oxidized [125I]LDL on human macrophages.
2002 Feb-Nov
Application of fluidized hot-melt granulation (FHMG) for the preparation of granules for tableting; properties of granules and tablets prepared by FHMG.
2002 Jan
Compactibility of mixtures of calcium carbonate and microcrystalline cellulose.
2002 Jan 1
Loss of regulation of lipogenesis in the Zucker diabetic rat. II. Changes in stearate and oleate synthesis.
2002 Mar
Investigation of excipient type and level on drug release from controlled release tablets containing HPMC.
2002 May
Geoglobus ahangari gen. nov., sp. nov., a novel hyperthermophilic archaeon capable of oxidizing organic acids and growing autotrophically on hydrogen with Fe(III) serving as the sole electron acceptor.
2002 May
Fatty acid mobilized by the vascular endothelial growth factor in human endothelial cells.
2002 Nov
Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. II. Study of roller compaction variables on granule and tablet properties by a 3(3) factorial design.
2002 Nov
Synthesis and selectin-binding activity of N-deacetylsialyl Lewis X ganglioside.
2002 Nov 19
Fatty acids carried on albumin modulate proximal tubular cell fibronectin production: a role for protein kinase C.
2002 Oct
Rheological properties of three component creams containing sorbitan monoesters as surfactants.
2002 Oct 24
Mixing of cohesive pharmaceutical formulations in tote (bin) blenders.
2002 Sep
Design of controlled release system with multi-layers of powder.
2002 Sep
Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles.
2002 Sep
Percutaneous absorption of inorganic lead compounds.
2002 Sep-Oct
Duration of coffee- and exercise-induced changes in the fatty acid profile of human serum.
2003 Feb
The influence of lipid nanocapsule composition on their size distribution.
2003 Jan
Distribution of vitamin A-storing lipid droplets in hepatic stellate cells in liver lobules--a comparative study.
2003 Mar
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: When these same investigators used a lower amount of dietary stearic acid (i.e., an increase of 3 g/day using milk chocolate) in a similar study, no differences in platelet aggregation or platelet activation activity were found
A stearic acid-rich diet (~ 7% of calories or 19 g/day) had beneficial effects on several measures of thrombosis (e.g., platelet volume, platelet aggregation, coagulation factor VII activity) in healthy males. Stearic acid was increased by 12 g/day using stearic acid-enriched margarine.
Route of Administration: Oral
Inhibition of EDR (endothelium-dependent relaxation) induced by acetylcholine was dose-dependent (0.5-2 mmol/l NEFA), and the greatest inhibition (51%) was observed with stearic acid (2 mmol/l).
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:51:16 UTC 2023
Edited
by admin
on Fri Dec 15 15:51:16 UTC 2023
Record UNII
37899330TZ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AMMONIUM STEARATE
INCI   MI  
INCI  
Official Name English
NOPCOTE DC 100A
Common Name English
OCTADECANOIC ACID, AMMONIUM SALT
Common Name English
VICARLAN BA
Common Name English
STEARIC ACID, AMMONIUM SALT
Common Name English
INS-470(I)STEARIC ACID, AMMONIUM SALT
Common Name English
LIGAFLUID AS 35
Common Name English
STANFAX 320
Common Name English
E-470(I)STEARIC ACID, AMMONIUM SALT
Common Name English
INS NO.470(I)STEARIC ACID, AMMONIUM SALT
Common Name English
STOKAL STA
Common Name English
AMMONIUM STEARATE [INCI]
Common Name English
KANEBINOL YC 81
Common Name English
AMMONIUM STEARATE [MI]
Common Name English
Classification Tree Code System Code
CODEX ALIMENTARIUS (GSFA) INS-470(I)
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
JECFA EVALUATION INS-470(I)
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
Code System Code Type Description
MERCK INDEX
m1820
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID0027353
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
PUBCHEM
61251
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
DAILYMED
37899330TZ
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
RXCUI
1312975
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
213-695-2
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
CAS
1002-89-7
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
FDA UNII
37899330TZ
Created by admin on Fri Dec 15 15:51:16 UTC 2023 , Edited by admin on Fri Dec 15 15:51:16 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE