Details
Stereochemistry | ACHIRAL |
Molecular Formula | C2H4N2 |
Molecular Weight | 56.0666 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC#N
InChI
InChIKey=DFNYGALUNNFWKJ-UHFFFAOYSA-N
InChI=1S/C2H4N2/c3-1-2-4/h1,3H2
Molecular Formula | C2H4N2 |
Molecular Weight | 56.0666 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Approval Year
PubMed
Title | Date | PubMed |
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Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. | 2008 Aug 27 |
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Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds. | 2008 May 1 |
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Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. | 2008 Nov 10 |
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IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions. | 2008 Nov 21 |
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Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system. | 2008 Oct |
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Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. | 2008 Oct 20 |
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Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. | 2008 Sep |
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The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. | 2008 Sep |
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Developing novel anthelmintics from plant cysteine proteinases. | 2008 Sep 1 |
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Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. | 2009 Apr |
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Safety of an amino-acetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration. | 2009 Aug |
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Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep. | 2009 Aug |
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Abstracts of the 2008 ISSOL Meeting. August 24-29, 2008. Florence, Italy. | 2009 Aug |
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The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America. | 2009 Dec |
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Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. | 2009 Dec |
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Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration. | 2009 Feb |
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Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration. | 2009 Feb |
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A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative ( AAD ), monepantel , in sheep in New Zealand. | 2009 Feb |
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Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. | 2009 Jan |
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Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep. | 2009 Jan 22 |
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The nicotinic acetylcholine receptors of the parasitic nematode Ascaris suum: formation of two distinct drug targets by varying the relative expression levels of two subunits. | 2009 Jul |
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Effect of fasting sheep for a short period on the efficacy and safety of monepantel. | 2009 Jul 11 |
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Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. | 2009 Mar |
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Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. | 2009 Mar 23 |
|
Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. | 2009 May |
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Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis. | 2009 Nov |
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Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. | 2009 Nov |
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Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. | 2009 Nov |
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Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling. | 2009 Nov 10 |
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Cyclocondensation of alpha-aminonitriles and enones: a short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles. | 2009 Nov 6 |
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ERK signalling pathway is not involved in PSA-NCAM-dependent alterations of hippocampal plasticity evoked by CB1 receptor activation. | 2009 Nov-Dec |
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Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal. | 2009 Oct |
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Reduction of nitrogen compounds in oceanic basement and its implications for HCN formation and abiotic organic synthesis. | 2009 Oct 22 |
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Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. | 2009 Sep |
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Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. | 2009 Sep 25 |
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Deep-space glycine formation via Strecker-type reactions activated by ice water dust mantles. A computational approach. | 2010 |
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Use of monepantel. | 2010 Apr 10 |
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Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep. | 2010 Apr 17 |
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Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. | 2010 Feb |
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Tholinomics--chemical analysis of nitrogen-rich polymers. | 2010 Feb 15 |
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[Determination of streptomycin in honey determined by hydrophilic interaction chromatography combined with tandem mass spectrometry]. | 2010 Jan |
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The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative. | 2010 Jan |
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A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep. | 2010 Jan |
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The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity. | 2010 Jan |
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Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning. | 2010 Jul |
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Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. | 2010 Jul 11 |
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Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis. | 2010 Jun |
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Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction. | 2010 Jun 24 |
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Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation. | 2010 Mar |
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The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel. | 2010 May 11 |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:35:38 GMT 2023
by
admin
on
Fri Dec 15 17:35:38 GMT 2023
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Record UNII |
3739OQ10IJ
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Record Status |
Validated (UNII)
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Record Version |
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m1676
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3739OQ10IJ
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D000607
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AMINOACETONITRILE
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208-751-8
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