Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C2H4N2 |
| Molecular Weight | 56.0666 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCC#N
InChI
InChIKey=DFNYGALUNNFWKJ-UHFFFAOYSA-N
InChI=1S/C2H4N2/c3-1-2-4/h1,3H2
| Molecular Formula | C2H4N2 |
| Molecular Weight | 56.0666 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. | 2001 Apr 1 |
|
| Kinetic studies of guinea pig liver transglutaminase reveal a general-base-catalyzed deacylation mechanism. | 2001 Jul 27 |
|
| Biochemical and toxicological evaluation of agent-cofactor reactivity as a mechanism of action for osteolathyrism. | 2002 Aug 15 |
|
| Utilization of glycine and serine as nitrogen sources in the roots of Zea mays and Chamaegigas intrepidus. | 2002 Dec |
|
| Mitochondrial oxidative burst involved in apoptotic response in oats. | 2002 Jun |
|
| Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model. | 2003 Feb 20 |
|
| A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. | 2003 Jan-Feb |
|
| Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats. | 2005 |
|
| A direct fluorometric assay for tissue transglutaminase. | 2005 Dec 15 |
|
| Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum. | 2006 |
|
| Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway. | 2006 |
|
| Diastereoselective arylithium addition to an alpha-trifluoromethyl imine. Practical synthesis of a potent cathepsin K inhibitor. | 2006 May 26 |
|
| A role for ERK2 in reconsolidation of fear memories in mice. | 2006 Sep |
|
| Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. | 2007 Oct |
|
| Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. | 2007 Sep 26 |
|
| Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. | 2008 Aug 27 |
|
| Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. | 2008 Nov 10 |
|
| IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions. | 2008 Nov 21 |
|
| Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. | 2008 Oct 20 |
|
| Identification of the amino-acetonitrile derivative monepantel (AAD 1566) as a new anthelmintic drug development candidate. | 2008 Sep |
|
| The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America. | 2009 Dec |
|
| Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration. | 2009 Feb |
|
| Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis. | 2009 Nov |
|
| Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. | 2009 Nov |
|
| Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. | 2009 Nov |
|
| Cyclocondensation of alpha-aminonitriles and enones: a short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles. | 2009 Nov 6 |
|
| Reduction of nitrogen compounds in oceanic basement and its implications for HCN formation and abiotic organic synthesis. | 2009 Oct 22 |
|
| Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. | 2009 Sep 25 |
|
| Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep. | 2010 Apr 17 |
|
| The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative. | 2010 Jan |
|
| A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep. | 2010 Jan |
|
| Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning. | 2010 Jul |
|
| Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. | 2010 Jul 11 |
|
| Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis. | 2010 Jun |
|
| Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction. | 2010 Jun 24 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 17:35:38 GMT 2023
by
admin
on
Fri Dec 15 17:35:38 GMT 2023
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| Record UNII |
3739OQ10IJ
|
| Record Status |
Validated (UNII)
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| Record Version |
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m1676
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3739OQ10IJ
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D000607
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AMINOACETONITRILE
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10901
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DTXSID90202314
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540-61-4
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208-751-8
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