Details
| Stereochemistry | MIXED |
| Molecular Formula | C11H15N3O5 |
| Molecular Weight | 269.2539 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O=C1N(CC2CO2)N(CC3CO3)C(=O)N1CC4CO4
InChI
InChIKey=ZTXDHEQQZVFGPK-UHFFFAOYSA-N
InChI=1S/C11H15N3O5/c15-10-12(1-7-4-17-7)11(16)14(3-9-6-19-9)13(10)2-8-5-18-8/h7-9H,1-6H2
| Molecular Formula | C11H15N3O5 |
| Molecular Weight | 269.2539 |
| Charge | 0 |
| Count |
|
| Stereochemistry | MIXED |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Anaxirone is a triepoxide compound with cytotoxic activity. By analogy with bifunctional epoxides, anaxirone probably acts as an alkylating agent. Despite a wide spectrum of activity against experimental tumors in rats and mice, clinical investigation of anaxirone has shown that the drug was inactive for the treatment of advanced colorectal cancer, advanced soft tissue sarcoma, small cell lung cancer, ovarian cancer, and advanced malignant melanoma.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| alpha-/beta-Triglycidyl-urazol (TGU, NSC 332488, I.N.N.: ANAXIRONE): a new chemotherapeutic agent. | 1984 Jun |
|
| Phase II trial of anaxirone (1,2,4-triglycidylurazol, TGU) in patients with advanced ovarian carcinoma: an EORTC Gynecological Cancer Cooperative Group Study. | 1987 Jun |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:37:07 GMT 2023
by
admin
on
Fri Dec 15 15:37:07 GMT 2023
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| Record UNII |
36R61Y789T
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| Record Status |
Validated (UNII)
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| Record Version |
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C475
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NCI_THESAURUS |
C574
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| Code System | Code | Type | Description | ||
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C041113
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CHEMBL2105991
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278-745-8
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332488
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77658-97-0
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100000086920
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SUB05503MIG
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71218
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DTXSID10868451
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5629
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C950
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36R61Y789T
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
