U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C14H17N3O.C4H6O4
Molecular Weight 361.3923
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FROVATRIPTAN SUCCINATE ANHYDROUS

SMILES

OC(=O)CCC(O)=O.CN[C@@H]1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(N)=O

InChI

InChIKey=WHTHWNUUXINXHN-SBSPUUFOSA-N
InChI=1S/C14H17N3O.C4H6O4/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8)/t9-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C14H17N3O
Molecular Weight 243.3043
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula C4H6O4
Molecular Weight 118.088
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Frovatriptan succinate (trade name Frova) is a selective 5-hydroxytryptamine1 (5-HT1B/1D) receptor subtype agonist, and is used for the treatment of migraine attacks with or without aura in adults. Frovatriptan has no significant effects on GABAA mediated channel activity and has no significant affinity for benzodiazepine binding sites. Frovatriptan is believed to act on extracerebral, intracranial arteries and to inhibit excessive dilation of these vessels in migraine. Serious but rare cardiac events have been reported in patients with risk factors predictive of coronary artery disease (CAD). These include coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation.

Originator

Approval Year

2001
194
Targets

Targets

Primary TargetPharmacologyConditionPotency
Agonist
2678
 62.0 nM [Ki]
Agonist
2678
 10.3 nM [Ki]
Agonist
2678
 4.4 nM [Ki]
Agonist
2678
Agonist
2678
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
FROVA

Approved Use

FROVA is indicated for the acute treatment of migraine attacks with or without aura in adults. FROVA is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). The safety and effectiveness of FROVA have not been established for cluster headache, which is present in an older, predominately male, population.

Launch Date

2001
Primary
Approved
8429
FROVA

Approved Use

FROVA is indicated for the acute treatment of migraine attacks with or without aura in adults. FROVA is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine (see CONTRAINDICATIONS). The safety and effectiveness of FROVA have not been established for cluster headache, which is present in an older, predominately male, population.

Launch Date

2001
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
2.44 ng/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25092964
2.5 mg single, oral
dose: 2.5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FROVATRIPTAN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
50.7 ng × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25092964
2.5 mg single, oral
dose: 2.5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FROVATRIPTAN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
29.3 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/25092964
2.5 mg single, oral
dose: 2.5 mg
route of administration: Oral
experiment type: SINGLE
co-administered:
FROVATRIPTAN plasma
Homo sapiens
population: UNHEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
85%
DRUG LABEL
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
FROVATRIPTAN serum
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
0.8 mg single, intravenous
Highest studied dose
Dose: 0.8 mg
Route: intravenous
Route: single
Dose: 0.8 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
healthy, 21 - 37
n = 12
Health Status: healthy
Age Group: 21 - 37
Sex: M+F
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
40 mg single, oral
Highest studied dose
Dose: 40 mg
Route: oral
Route: single
Dose: 40 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
healthy, 21 - 37
n = 12
Health Status: healthy
Age Group: 21 - 37
Sex: M+F
Population Size: 12
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028321
Page: S56
40 mg single, oral
Highest studied dose
Dose: 40 mg
Route: oral
Route: single
Dose: 40 mg
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028323
Page: S76
unhealthy, 40.4
n = 207
Health Status: unhealthy
Condition: Migraine
Age Group: 40.4
Sex: M+F
Population Size: 207
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028323
Page: S76
Sources:
https://pubmed.ncbi.nlm.nih.gov/12028323
Page: S76
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Disc. AE: Arrhythmia, Cerebral hemorrhage...
Other AEs: Myocardial ischemia, Myocardial infarction...
AEs leading to
discontinuation/dose reduction:
Arrhythmia
Cerebral hemorrhage
Subarachnoid hemorrhage
Stroke
Gastrointestinal ischemia
Peripheral vasoconstriction
Serotonin syndrome
Other AEs:
Myocardial ischemia
Myocardial infarction
Prinzmetal angina
Chest pain
Throat pain
Neck pain
Jaw pain
Chest tightness
Throat tightness
Pressure
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Disc. AE: Splenic infarction, Raynaud's syndrome...
AEs leading to
discontinuation/dose reduction:
Splenic infarction
Raynaud's syndrome
Blood pressure high (grade 3)
Hypertensive crisis
Anaphylactic reaction (grade 4-5)
Anaphylactoid reaction (grade 4-5)
Angioedema (grade 4-5)
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
AEs

AEs

AESignificanceDosePopulation
Chest pain
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Chest tightness
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Jaw pain
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Myocardial infarction
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Myocardial ischemia
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Neck pain
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Pressure
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Prinzmetal angina
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Throat pain
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Throat tightness
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Arrhythmia Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Cerebral hemorrhage Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Gastrointestinal ischemia Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Peripheral vasoconstriction Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Serotonin syndrome Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Stroke Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Subarachnoid hemorrhage Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.1
Hypertensive crisis Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Raynaud's syndrome Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Splenic infarction Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Blood pressure high grade 3
Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Anaphylactic reaction grade 4-5
Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Anaphylactoid reaction grade 4-5
Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Angioedema grade 4-5
Disc. AE
7.5 mg 3 times / day multiple, oral
Recommended
Dose: 7.5 mg, 3 times / day
Route: oral
Route: multiple
Dose: 7.5 mg, 3 times / day
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
unhealthy
Health Status: unhealthy
Condition: Migraine
Sources:
https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021006s019lbl.pdf
Page: p.3
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG
inhibitor
1587

inducer
781

substrate
1737
substrate
1037
inhibitor
1852

substrate
1217

OverviewOther

Other InhibitorOther SubstrateOther Inducer
CYP1A2
1524

CYP2C8/9
44

CYP2C19
1478

CYP2E1
882
CYP1A2
1054
CYP1A2
701

CYP4A
14
Drug as perpetrator​

Drug as perpetrator​

TargetModalityActivityMetaboliteClinical evidence
CYP1A2
1692
 no
CYP1A2
1692
 no
CYP2C19
1553
 no
CYP2C8/9
44
 no
CYP2D6
1891
 no
CYP2E1
970
 no
CYP3A4
1925
 no
CYP3A4
1925
 no
CYP4A
33
 no
Drug as victim

Drug as victim

TargetModalityActivityMetaboliteClinical evidence
CYP2C9
1037
 no
CYP2D6
1217
 no
CYP3A4
1737
 no
CYP1A2
1054
 yes
Sourcing

Sourcing

Vendor/AggregatorIDURL
ABI Chem
AC1L2U95
AN PharmaTech
AN-5267
Alsachim
4232
http://www.alsachim.com/product-C5550-glo.bal-view.html
Angene
AGN-PC-0Q7KOZ
BLD Pharm
BD131596
http://www.bldpharm.com/products/158747-02-5.html
BOC Sciences
147009-08-3
BOC Sciences
158930-09-7
BOC Sciences
158930-17-7
Chem Scene
CS-0021309
ChemMol
44000939
http://www.chemmol.com/chemmol/44000939.html
ChemMol
49400089
http://www.chemmol.com/chemmol/49400089.html
ChemShuttle
159065
Chemieliva Pharmaceutical Co., Ltd
PBCM1202367
Compound Cloud
152943
Compound Cloud
77992
DC Chemicals
DC22890
http://www.dcchemicals.com/product_show-DC22890.html
Hangzhou APIChem Technology
AC-4258
MolPort
MolPort-046-196-805
Molnova
M12269
MuseChem
M105240
https://www.musechem.com/product/M105240.html
Norris Pharm
NSZB-A219176
NovoSeek
77992
Parchem
29025
http://www.parchem.com/chemical-supplier-distributor/Frovatriptan-019025.aspx
Selleck Chemicals
S5848
Sigma Aldrich
1286413
Sigma Aldrich
1286413|USP
Sigma Aldrich
SML1291
Sigma Aldrich
SML1291|SIGMA
Smolecule
S528497
http://www.smolecule.com/products/s528497
THE BioTek
bt-268779
https://www.thebiotek.com/product/inhibitors/bt-268779
THE BioTek
bt-406286
https://www.thebiotek.com/product/others/bt-406286
Toronto Research Chemicals
M198100
Wonderchem
WD05AWA
Wonderchem
WD05AWB
ZINC
ZINC000000018635
http://zinc15.docking.org/substances/ZINC000000018635
eMolecules
225791104
eMolecules
300452900
eMolecules
45916583
eMolecules
48667526
eMolecules
76760210
eNovation Chemicals
D380881
PubMed

PubMed

TitleDatePubMed
Comparative aspects of triptans in treating migraine.
2001
Spotlight on rizatriptan in migraine.
2002
Tolerability and safety of frovatriptan with short- and long-term use for treatment of migraine and in comparison with sumatriptan.
2002 Apr
Clinical efficacy of frovatriptan: placebo-controlled studies.
2002 Apr
Clinical pharmacokinetics of frovatriptan.
2002 Apr
[Treatment of migraine in patients with hypertension and ischemic heart disease].
2002 Jan 20
Gateways to Clinical Trials. June 2002.
2002 Jun
Gateways to clinical trials.
2002 Nov
Newer formulations of the triptans: advances in migraine management.
2003
Pharmacological approaches to migraine.
2003
[Migraine therapy. new specific triptan frovatriptan--long acting].
2003 Jan
Frovatriptan: a review.
2003 Jan
The truth about frovatriptan.
2003 Jun
Gateways to clinical trials.
2004 Apr
Tracheostomy must be individualized!
2004 Oct
The use of triptans in the management of menstrual migraine.
2005
Evidence for 5-HT2B and 5-HT7 receptor-mediated relaxation in pulmonary arteries of weaned pigs.
2005 Jan
A randomized trial of frovatriptan for the intermittent prevention of menstrual migraine.
2005 Mar 8
[Tracheotomy and tracheostomy techniques].
2005 May
Tracheal intubation using a classic laryngeal mask airway, Frova introducer, and pediatric bronchoscope.
2006 Dec
A validated chiral CE method for Frovatriptan, using cyclodextrin as chiral selector.
2006 Jun 16
Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine.
2006 Sep
New pain management options: drugs.
2007 Jan
In silico prediction of pregnane X receptor activators by machine learning approaches.
2007 Jan
Frovatriptan for the prevention of postdural puncture headache.
2007 Jul
Frovatriptan vs. transdermal oestrogens or naproxen sodium for the prophylaxis of menstrual migraine.
2007 Oct
Patents

Patents

20020049202
5
JP2002521446A
10
JP2011510954A
143

Sample Use Guides

In Vivo Use Guide
The recommended dose is a single tablet of FROVA (frovatriptan 2.5 mg) taken orally with fluids. If the headache recurs after initial relief, a second tablet may be taken, providing there is an interval of at least 2 hours between doses. The total daily dose of frovatriptan should not exceed 3 tablets (3 x 2.5 mg per day). The safety of treating an average of more than 4 migraine attacks in a 30-day period has not been established.
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Frovatriptan was investigated in human isolated basilar and coronary arteries in which the endothelium had been removed. Basilar arteries were obtained post mortem, and coronary arteries were obtained from patients undergoing heart transplant (recipient) or from donor hearts that were not suitable for transplant. Frovatriptan was a potent contractile agent in isolated basilar artery with a -log mean effective concentration (EC50) value of 7.86 +/- 0.07 and intrinsic activity of 1.25 +/- 0.10 relative to 5-HT (n = 4). In coronary arteries, frovatriptan produced contraction with -log EC50 values of 7.38 +/- 0.12 and 7.81 +/- 0.2 in recipient (n = 7) and donor (n = 3) arteries, respectively. The relative degree of contraction of frovatriptan was lower than that of 5-HT, with relative intrinsic activities of 0.42 +/- 0.06 and 0.40 +/- 0.09, respectively.
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 05:59:32 GMT 2023
Edited
by admin
on Sat Dec 16 05:59:32 GMT 2023
Record UNII
36K05YF32G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FROVATRIPTAN SUCCINATE ANHYDROUS
MI  
Common Name English
FROVATRIPTAN SUCCINATE ANHYDROUS [MI]
Common Name English
BUTANEDIOIC ACID, COMPD. WITH (3R)-2,3,4,9-TETRAHYDRO-3-(METHYLAMINO)-1H-CARBAZOLE-6-CARBOXAMIDE (1:1)
Common Name English
(+)-(R)-2,3,4,9-TETRAHYDRO-3-(METHYLAMINO)-1H-CARBAZOLE-6-CARBOXAMIDE BUTANEDIOATE (1:1)
Systematic Name English
Code System Code Type Description
SMS_ID
100000088414
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
CAS
158930-09-7
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
DRUG BANK
DBSALT001957
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
PUBCHEM
152944
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
MERCK INDEX
m5571
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID90166543
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
FDA UNII
36K05YF32G
Created by admin on Sat Dec 16 05:59:32 GMT 2023 , Edited by admin on Sat Dec 16 05:59:32 GMT 2023
PRIMARY
Related Record Type Details
Structure of Frovatriptan Succinate
SOLVATE->ANHYDROUS
NIH
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