Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H24O5 |
| Molecular Weight | 320.3802 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C[C@H]1CCC[C@@H](O)CCC\C=C\C2=C(C(O)=CC(O)=C2)C(=O)O1
InChI
InChIKey=FPQFYIAXQDXNOR-PMRAARRBSA-N
InChI=1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14-/m0/s1
| Molecular Formula | C18H24O5 |
| Molecular Weight | 320.3802 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27311894 | https://www.ncbi.nlm.nih.gov/pubmed/485136 | https://www.ncbi.nlm.nih.gov/pubmed/26335359 | https://www.ncbi.nlm.nih.gov/pubmed/26308051
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/27311894 | https://www.ncbi.nlm.nih.gov/pubmed/485136 | https://www.ncbi.nlm.nih.gov/pubmed/26335359 | https://www.ncbi.nlm.nih.gov/pubmed/26308051
β-Zearalenol is a nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in Fusarium spp. β-Zearalenol is the β epimer of α-zearalenol and along with α-zearalenol is a major metabolite of zearalenone formed mainly in the liver but also to a lesser extent in the intestines during the first-pass metabolism. β-Zearalenol is about the same or slightly less potent as an estrogen relative to zearalenone. Contamination of grains by Fusarium species, notably maize, gives rise to high levels of zearalenol and is regarded as an important food quality issue for both human and animal health.
Approval Year
Sample Use Guides
Cytotoxicity assay against African green monkey kidney fibroblast (Vero) cells was performed in triplicate employing the colorimetric method. Cells were grown in culture flasks or, for experiments, multiwell plates (TPP, Winiger, Wohlen, Switzerland) in DMEM/F12 1:1 medium (Life Technologies, Basel, Swit-zerland) supplemented with 5% fetal calf serum (FCS) (Sera-Tech) and incubated at 37°C in a humidified 5% CO2 atmosphere. Twice a week, cells were detached by treat-ment with trypsin-EDTA (Life Technologies), counted, and subcultured at ratios between 1:5 and 1:20. Cell samples were counted in duplicate and viability was determined using the trypan blue exclusion method.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 00:26:34 GMT 2023
by
admin
on
Sat Dec 16 00:26:34 GMT 2023
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| Record UNII |
35E809PP7O
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID8022533
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beta-Zearalenol
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71030-11-0
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35E809PP7O
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6437352
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admin on Sat Dec 16 00:26:34 GMT 2023 , Edited by admin on Sat Dec 16 00:26:34 GMT 2023
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