Suvonstobart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 19:43:55 GMT 2025` Edited by `admin` on `Wed Apr 02 19:43:55 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	359SBX4N6E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Suvonstobart

Official Name

English

IMM-47

Preferred Name

English

suvonstobart [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CD24 (signal transducer CD24)], monoclonal antibody; H-gamma1 heavy chain (1-447) [VH Musmus/Homsap (Mus musculus IGHV3-1*02 (98.0%) -(IGHD) -IGHJ4*01 (87.5%) G121>R (110)/Homo sapiens IGHV4-30-4*09 (74.5%) -(I

Common Name

English

IMM47

Code

English

Immunoglobulin G1 [298-alanine,333-alanine,334-alanine], anti-(human CD24 antigen) (human-Mus musculus monoclonal IMM47 ?1-chain), disulfide with human-Mus musculus monoclonal IMM47 ?-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

359SBX4N6E

Created by admin on Wed Apr 02 19:43:55 GMT 2025 , Edited by admin on Wed Apr 02 19:43:55 GMT 2025

PRIMARY

CAS

2983834-87-1

Created by admin on Wed Apr 02 19:43:55 GMT 2025 , Edited by admin on Wed Apr 02 19:43:55 GMT 2025

PRIMARY

INN

13347

Created by admin on Wed Apr 02 19:43:55 GMT 2025 , Edited by admin on Wed Apr 02 19:43:55 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_144	2_200
2_220	4_220
2_261	2_321
1_144	1_200
2_367	2_425
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_220	3_220
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					B20QL1Z44W

CD24

TARGET->LIGAND

Amount:

Related Record Type Details


					359SBX4N6E

Suvonstobart

ACTIVE MOIETY

Comments:

Achieved significant inhibitory effect on tumor growth

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL