GONIOTHALAMIN

O=C1O[C@H](CC=C1)\C=C\C2=CC=CC=C2

InChIKey=RLGHFVLWYYVMQZ-BZYZDCJZSA-N

InChI=1S/C13H12O2/c14-13-8-4-7-12(15-13)10-9-11-5-2-1-3-6-11/h1-6,8-10,12H,7H2/b10-9+/t12-/m1/s1

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	1
Optical Activity	UNSPECIFIED

PubMed

Title	Date	PubMed
Gastroprotective effects of goniothalamin against ethanol and indomethacin-induced gastric lesions in rats: Role of prostaglandins, nitric oxide and sulfhydryl compounds.	2014-12-05	25451594
Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation.	2013-09	23845509
Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells.	2011-10-01	21810437
Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway.	2010-08	20498002
Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells.	2010-03-01	20026395
RACK-1 overexpression protects against goniothalamin-induced cell death.	2009-12-15	19698770
Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy.	2008-11-25	18771661

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:53:51 GMT 2025` Edited by `admin` on `Mon Mar 31 19:53:51 GMT 2025`
Record UNII	34W9GO6B2Z
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

GONIOTHALAMIN

Common Name

English

(6R)-6.ALPHA.-((E)-STYRYL)-5,6-DIHYDRO-2H-PYRAN-2-ONE

Preferred Name

English

(R)-(+)-GONIOTHALAMIN

Common Name

English

Code System Code Type Description

FDA UNII

34W9GO6B2Z