Sotiburafusp Alfa

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 16:21:58 UTC 2023` Edited by `admin` on `Sat Dec 16 16:21:58 UTC 2023`
Protein Type	BISPECIFIC ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	34DTV38QW5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Sotiburafusp Alfa

Official Name

English

sotiburafusp alfa [INN]

Common Name

English

humanized vascular endothelial growth factor receptor 1 (VEGFR-1, Fms-like tyrosine kinase 1, FLT-1) extracellular domain fragment (129-228, 1-100 in the current sequence) fused via the peptide linker 101 GGSGGSGGSGGSGGS115 to the N-terminus of the heavy

Common Name

English

103-202-Vascular endothelial growth factor receptor 1 (human gene VEGFR1D2) fusion protein with peptide linker (GGS)5 fusion protein with immunoglobulin G1 [352-alanine,353-alanine,de-C-terminal-lysine], anti-(human programmed death-ligand 1) (human-Mus

Common Name

English

Code System Code Type Description

INN

12407

Created by admin on Sat Dec 16 16:21:58 UTC 2023 , Edited by admin on Sat Dec 16 16:21:58 UTC 2023

PRIMARY

FDA UNII

34DTV38QW5

Created by admin on Sat Dec 16 16:21:58 UTC 2023 , Edited by admin on Sat Dec 16 16:21:58 UTC 2023

PRIMARY

CAS

2637466-37-4

Created by admin on Sat Dec 16 16:21:58 UTC 2023 , Edited by admin on Sat Dec 16 16:21:58 UTC 2023

PRIMARY

NCI_THESAURUS

C179665

Created by admin on Sat Dec 16 16:21:58 UTC 2023 , Edited by admin on Sat Dec 16 16:21:58 UTC 2023

PRIMARY

From	To
4_139	4_199
4_23	4_93
3_139	3_199
3_23	3_93
2_485	2_543
2_379	2_439
2_338	4_219
2_262	2_318
2_137	2_211
2_30	2_79
1_485	1_543
1_379	1_439
1_347	2_347
1_344	2_344
1_338	3_219
1_262	1_318
1_137	1_211
1_30	1_79

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_36
N	1_68
N	1_415
N	2_36
N	2_68
N	2_415

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET -> INHIBITOR

Interaction Type:

IN-VITRO

Amount:


					NZN256ZSV8

HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR A

TARGET -> INHIBITOR

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					34DTV38QW5

Sotiburafusp Alfa

ACTIVE MOIETY

Comments:

HB0025 inhibited VEGF-stimulated proliferation (IC50 = 12.84 nM) and migration of cultured human HUVEC epithelial cells

Interaction Type:

IN-VITRO

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:WEIGHT AVERAGE	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL