Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C24H27ClN2O2S |
| Molecular Weight | 443.001 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)OCCN1CCN(CC\C=C2\C3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3)CC1
InChI
InChIKey=OXAUOBQMCDIVPQ-IOXNKQMXSA-N
InChI=1S/C24H27ClN2O2S/c1-18(28)29-16-15-27-13-11-26(12-14-27)10-4-6-20-21-5-2-3-7-23(21)30-24-9-8-19(25)17-22(20)24/h2-3,5-9,17H,4,10-16H2,1H3/b20-6-
| Molecular Formula | C24H27ClN2O2S |
| Molecular Weight | 443.001 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26624987
Curator's Comment: Description was created based on several sources, including
https://www.lundbeck.com/upload/au/files/pdf/Clopixol_CMI.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26624987
Zuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness. Zuclopenthixol, a thioxanthene derivative, has high affinity for both dopamine D1 receptors and
dopamine D2 receptors. Zuclopenthixol also has high affinity for α1-adrenergic and 5-HT2
receptors. Zuclopenthixol (CLOPIXOL®) is avavilable in the form of tablets and solution for intramuscular injections.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL217 |
|||
Target ID: CHEMBL2056 |
|||
Target ID: CHEMBL2094251 |
|||
Target ID: CHEMBL2093870 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | CLOPIXOL Approved UseZuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness. |
|||
| Primary | CLOPIXOL Approved UseZuclopenthixol is indicated the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behaviour. It is also used to treat the manic phase of manic depressive illness. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy. | 1967 |
|
| The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria. | 1986 Dec |
|
| Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime. | 1987 Jan |
|
| Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study. | 1987 Jul |
|
| Zuclopenthixol and haloperidol/levomepromazine in the treatment of elderly patients with symptoms of aggressiveness and agitation: a double-blind, multi-centre study. | 1989 |
|
| Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology. | 1989 May |
|
| Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia. | 1991 Dec |
|
| [acute dystonias in combined abuse of cocaine and neuroleptics]. | 1994 Nov 26 |
|
| Effect of some psychotropic drugs and a barbiturate on mycoplasmas. | 2000 Apr |
|
| Antipsychotic-induced extrapyramidal syndromes. Risperidone compared with low- and high-potency conventional antipsychotic drugs. | 2001 Jul |
|
| Clozapine and weight gain. | 2001 May |
|
| Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms. | 2003 Jul |
|
| Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. | 2004 Aug |
|
| Long term results of unilateral posteroventral pallidotomy for antipsychotic drug induced tardive dyskinesia. | 2005 Jul |
|
| [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
|
| Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine. | 2007 Fall |
|
| Remission of schizophrenia psychosis and strong reduction of obsessive-compulsive disorder after adding clozapine to aripiprazole. | 2009 Nov 13 |
|
| Severe laryngeal dystonia in a patient receiving zuclopenthixol "Acuphase" and fluoxetine. | 2010 Apr |
|
| Zuclopenthixol acetate for acute schizophrenia and similar serious mental illnesses. | 2012 Apr 18 |
|
| Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry. | 2012 Sep |
|
| Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. | 2014 Mar |
|
| Paradoxical severe agitation induced by add-on high-doses quetiapine in schizo-affective disorder. | 2014 May 15 |
Patents
Sample Use Guides
Clopixol tablets: The usual dose is 10 to 50 mg per
day.
Clopixol Acuphase injection: The usual dose is 50 to 150 mg (1 to 3 mL) every 2 to 3 days or as
instructed by your doctor.
Clopixol Depot injection: The usual dose is 200 to 400 mg (1 to 2 mL) every second to fourth week.
Route of Administration:
Other
| Substance Class |
Chemical
Created
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349S2ZHF05
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Validated (UNII)
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C29710
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