GSK-3008348

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H37N5O2.ClH
Molecular Weight	524.097
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CC1=NN(C(C)=C1)C2=CC(=CC=C2)[C@@H](CN3CC[C@@H](CCC4=NC5=C(CCCN5)C=C4)C3)CC(O)=O

InChI

InChIKey=GCZLVFRSWWTRPH-DYNCTKRQSA-N

InChI=1S/C29H37N5O2.ClH/c1-20-15-21(2)34(32-20)27-7-3-5-24(16-27)25(17-28(35)36)19-33-14-12-22(18-33)8-10-26-11-9-23-6-4-13-30-29(23)31-26;/h3,5,7,9,11,15-16,22,25H,4,6,8,10,12-14,17-19H2,1-2H3,(H,30,31)(H,35,36);1H/t22-,25-;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C29H37N5O2
Molecular Weight	487.6364
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Integrin alpha-V/beta-6 3 Target ID: CHEMBL2111416 Sources: https://adisinsight.springer.com/drugs/800043800 \| https://www.ncbi.nlm.nih.gov/pubmed/29532104	Antagonist 2849

C_max

Value	Dose	Analyte	Population
102 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	30 μg single, respiratory dose: 30 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
501 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	100 μg single, respiratory dose: 100 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1922 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	300 μg single, respiratory dose: 300 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7243 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	1000 μg single, respiratory dose: 1000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
29393 pg/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	3000 μg single, respiratory dose: 3000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

AUC

Value	Dose	Analyte	Population
285 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	30 μg single, respiratory dose: 30 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
1765 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	100 μg single, respiratory dose: 100 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
6850 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	300 μg single, respiratory dose: 300 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
29093 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	1000 μg single, respiratory dose: 1000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
82205 pg × h/mL EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	3000 μg single, respiratory dose: 3000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

T_1/2

Value	Dose	Analyte	Population
10.2 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	100 μg single, respiratory dose: 100 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
10.1 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	300 μg single, respiratory dose: 300 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
8.97 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	1000 μg single, respiratory dose: 1000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN
7.95 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/29532104/	3000 μg single, respiratory dose: 3000 μg route of administration: Respiratory experiment type: SINGLE co-administered:	GSK-3008348 plasma	Homo sapiens population: HEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN

PubMed

Title	Date	PubMed
Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants.	2018-06	29532104

Substance Class	Chemical Created by `admin` on `Wed Apr 02 21:26:01 GMT 2025` Edited by `admin` on `Wed Apr 02 21:26:01 GMT 2025`
Record UNII	33W7SJ9TBX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GSK3008348

Preferred Name

English

GSK-3008348

Common Name

English

(3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acid hydrochloride

Systematic Name

English

GSK3008348 monohydrochloride

Common Name

English

1-Pyrrolidinebutanoic acid, ?-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (?S,3R)-, hydrochloride

Systematic Name

English

GSK3008348E

Common Name

English

Code System Code Type Description

PUBCHEM

86272868

Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025

PRIMARY

CAS

2365406-14-8

Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025

PRIMARY

SMS_ID

300000056504

Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025

PRIMARY

FDA UNII

33W7SJ9TBX

Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025

PRIMARY

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ACTIVE MOIETY

Amount:

Details

SMILES

InChI

Approval Year

Targets

Cmax

AUC

T1/2

PubMed

C_max

T_1/2