U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C29H37N5O2.ClH
Molecular Weight 524.097
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-3008348

SMILES

Cl.CC1=NN(C(C)=C1)C2=CC(=CC=C2)[C@@H](CN3CC[C@@H](CCC4=NC5=C(CCCN5)C=C4)C3)CC(O)=O

InChI

InChIKey=GCZLVFRSWWTRPH-DYNCTKRQSA-N
InChI=1S/C29H37N5O2.ClH/c1-20-15-21(2)34(32-20)27-7-3-5-24(16-27)25(17-28(35)36)19-33-14-12-22(18-33)8-10-26-11-9-23-6-4-13-30-29(23)31-26;/h3,5,7,9,11,15-16,22,25H,4,6,8,10,12-14,17-19H2,1-2H3,(H,30,31)(H,35,36);1H/t22-,25-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C29H37N5O2
Molecular Weight 487.6364
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
102 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
30 μg single, respiratory
dose: 30 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
501 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
100 μg single, respiratory
dose: 100 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1922 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
300 μg single, respiratory
dose: 300 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
7243 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
1000 μg single, respiratory
dose: 1000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
29393 pg/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
3000 μg single, respiratory
dose: 3000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
285 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
30 μg single, respiratory
dose: 30 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
1765 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
100 μg single, respiratory
dose: 100 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
6850 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
300 μg single, respiratory
dose: 300 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
29093 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
1000 μg single, respiratory
dose: 1000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
82205 pg × h/mL
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
3000 μg single, respiratory
dose: 3000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
10.2 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
100 μg single, respiratory
dose: 100 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
10.1 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
300 μg single, respiratory
dose: 300 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
8.97 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
1000 μg single, respiratory
dose: 1000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
7.95 h
EXPERIMENT
https://pubmed.ncbi.nlm.nih.gov/29532104/
3000 μg single, respiratory
dose: 3000 μg
route of administration: Respiratory
experiment type: SINGLE
co-administered:
GSK-3008348 plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
PubMed

PubMed

TitleDatePubMed
Substance Class Chemical
Created
by admin
on Wed Apr 02 21:26:01 GMT 2025
Edited
by admin
on Wed Apr 02 21:26:01 GMT 2025
Record UNII
33W7SJ9TBX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GSK3008348
Preferred Name English
GSK-3008348
Common Name English
(3S)-3-[3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl]-4-[(3R)-3-[2-(1,5,6,7-tetrahydro-1,8-naphthyridin-2-yl)ethyl]pyrrolidin-1-yl]butanoic acid hydrochloride
Systematic Name English
GSK3008348 monohydrochloride
Common Name English
1-Pyrrolidinebutanoic acid, ?-[3-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl]-3-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl]-, (?S,3R)-, hydrochloride
Systematic Name English
GSK3008348E
Common Name English
Code System Code Type Description
PUBCHEM
86272868
Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025
PRIMARY
CAS
2365406-14-8
Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025
PRIMARY
SMS_ID
300000056504
Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025
PRIMARY
FDA UNII
33W7SJ9TBX
Created by admin on Wed Apr 02 21:26:01 GMT 2025 , Edited by admin on Wed Apr 02 21:26:01 GMT 2025
PRIMARY
Related Record Type Details
Structure of GSK-3008348 FREE BASE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of GSK-3008348 FREE BASE
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966