TOMLIGISIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 15:11:12 GMT 2023` Edited by `admin` on `Sat Dec 16 15:11:12 GMT 2023`
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	33QVW0C7EK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TOMLIGISIRAN SODIUM

Common Name

English

RNA, ((1'-DE(6-AMINO-9H-PURIN-9-YL))DA-(5'->5')-CM-GM-CM-UM-GM-UM-AM-GM-(2'-DEOXY-2'-FLUORO)G-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)A-UM-AM-AM-AM-UM-UM-GM-GM-UM-AM-(3'->3')-SP-(1'-DE(6-AMINO-9H-PURIN-9-YL))DA), 3'-(O-(CIS-4-((3S,8S)-17-((2-(ACETYLAMI

Common Name

English

Code System Code Type Description

FDA UNII

33QVW0C7EK

Created by admin on Sat Dec 16 15:11:12 GMT 2023 , Edited by admin on Sat Dec 16 15:11:12 GMT 2023

PRIMARY

CAS

2202803-58-3

Created by admin on Sat Dec 16 15:11:12 GMT 2023 , Edited by admin on Sat Dec 16 15:11:12 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_8;1_12-1_21;2_1;2_3;2_5;2_7;2_9;2_11;2_13;2_15;2_17;2_19-2_21	30 / 42
2'-Fluoro-Ribose	1_9-1_11;2_2;2_4;2_6;2_8;2_10;2_12;2_14;2_16;2_18	12 / 42

Linkage	Site Range	Site Count
Sodium Phosporothioate	2_2-2_4;2_21	4 / 40
	1_2-1_21;2_5-2_20	36 / 40

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	db908b7b (not in database)
NUCLEOTIDE SUBSTITUTION	[1_21]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	33b83772 (not in database)