Approval Year
Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 11:42:46 GMT 2023
by
admin
on
Sat Dec 16 11:42:46 GMT 2023
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Protein Sub Type | |
Sequence Type | COMPLETE |
Record UNII |
33M0S99YTT
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Record Status |
Validated (UNII)
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Record Version |
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-
Download
Name | Type | Language | ||
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Common Name | English | ||
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Common Name | English | ||
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Systematic Name | English |
Code System | Code | Type | Description | ||
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33M0S99YTT
Created by
admin on Sat Dec 16 11:42:47 GMT 2023 , Edited by admin on Sat Dec 16 11:42:47 GMT 2023
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PRIMARY | |||
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MINERALOCORTICOID RECEPTOR
Created by
admin on Sat Dec 16 11:42:47 GMT 2023 , Edited by admin on Sat Dec 16 11:42:47 GMT 2023
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PRIMARY |
Linkage Type | Residue Index | |||
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COORDINATION COMPOUND | 1_639 | 1_645 | 1_655 | 1_658 |
COORDINATION COMPOUND | 1_603 | 1_606 | 1_620 |
Related Record | Type | Details | ||
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INHIBITOR -> TARGET |
Is a prodrug that Inhibits through active metabolites.
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INHIBITOR -> TARGET |
INHIBITOR
IC50
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PARTIAL ANTAGONIST->TARGET |
AZD9977 is a partial MR antagonist due to its unique interaction pattern with MR, which results in a distinct recruitment of co-factor peptides when compared to eplerenone. AZD9977 dose dependently reduced albuminuria and improved kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats. In acute testing, AZD9977 did not affect urinary Na+/K+ ratio
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET |
Luciferase transactivation assay in CV-1 (African green monkey kidney) cells transfected with hMR expression vectors
AGONIST
EC50
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET | |||
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INHIBITOR -> TARGET |
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INHIBITOR -> TARGET |
ANTAGONIST
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AGONIST -> TARGET |
Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
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MOL_WEIGHT | CHEMICAL |
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