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Approval Year

Substance Class Protein
Created
by admin
on Sat Jun 26 23:45:18 UTC 2021
Edited
by admin
on Sat Jun 26 23:45:18 UTC 2021
Protein Sub Type
Sequence Type COMPLETE
Record UNII
33M0S99YTT
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MINERALOCORTICOID RECEPTOR
Common Name English
ALDOSTERONE RECEPTOR
Common Name English
NUCLEAR RECEPTOR SUBFAMILY 3, GROUP C, MEMBER 2,
Systematic Name English
Code System Code Type Description
FDA UNII
33M0S99YTT
Created by admin on Sat Jun 26 23:45:19 UTC 2021 , Edited by admin on Sat Jun 26 23:45:19 UTC 2021
PRIMARY
WIKIPEDIA
MINERALOCORTICOID RECEPTOR
Created by admin on Sat Jun 26 23:45:19 UTC 2021 , Edited by admin on Sat Jun 26 23:45:19 UTC 2021
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
Is a prodrug that Inhibits through active metabolites.
INHIBITOR -> TARGET
INHIBITOR
IC50
PARTIAL ANTAGONIST->TARGET
AZD9977 is a partial MR antagonist due to its unique interaction pattern with MR, which results in a distinct recruitment of co-factor peptides when compared to eplerenone. AZD9977 dose dependently reduced albuminuria and improved kidney histopathology similar to eplerenone in db/db uni-nephrectomised mice and uni-nephrectomised rats. In acute testing, AZD9977 did not affect urinary Na+/K+ ratio
AGONIST -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Luciferase transactivation assay in CV-1 (African green monkey kidney) cells transfected with hMR expression vectors
AGONIST
EC50
INHIBITOR -> TARGET
AGONIST -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
AGONIST -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT CHEMICAL