Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Br.Rb |
| Molecular Weight | 165.372 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Br-].[Rb+]
InChI
InChIKey=JAAGVIUFBAHDMA-UHFFFAOYSA-M
InChI=1S/BrH.Rb/h1H;/q;+1/p-1
| Molecular Formula | Rb |
| Molecular Weight | 85.4678 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | BrH |
| Molecular Weight | 80.912 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/3311597 | https://www.ncbi.nlm.nih.gov/pubmed/26442267
Rubidium chloride is an inorganic compound with the formula RbCl. It appears to be nontoxic and therapeutically effective in several types of depressive disorders. This drug develops his action on dopaminergic stimulation reducing the depressive pattern. Also radioactive rubidium-82 chloride is used as diagnostic agent in positron emission tomography (PET).
CNS Activity
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Brain norepinephrine: enhanced turnover after rubidium treatment. | 1970 Apr 24 |
|
| Nerve fibre refractory period in patients treated with rubidium and lithium. | 1978 Sep |
|
| Exploration of the clinical profile of rubidium chloride in depression: a systematic open trial. | 1988 Jun |
Patents
Sample Use Guides
Rubidium chloride accelerated cAMP synthesis in rat brain cortex membranes. The effect was dose-dependent and yielded above 2-fold activation of adenylate cyclase. It has been shown that Rb+ influenced directly the catalytic subunit of the enzyme and did not substitute Mg2+ in formation of the metal-ATP complex in this reaction. The stimulatory effect of Rb+ was additive to the activation of adenylate cyclase by the half-maximal (0.3 microM) as well as by the saturating (10 microM) forskolin concentrations, pointing to the fact that these effectors activate different isoforms of the enzyme in rat brain cortex.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:45:22 GMT 2023
by
admin
on
Sat Dec 16 08:45:22 GMT 2023
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| Record UNII |
33CM31XVQQ
|
| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID00894885
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7789-39-1
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33CM31XVQQ
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4670918
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RUBIDIUM BROMIDE
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m9686
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232-162-5
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