TRIBUTYLTIN OXIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H54OSn2
Molecular Weight	596.105
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC

InChI

InChIKey=APQHKWPGGHMYKJ-UHFFFAOYSA-N

InChI=1S/6C4H9.O.2Sn/c6*1-3-4-2;;;/h6*1,3-4H2,2H3;;;

HIDE SMILES / InChI

Molecular Formula	C24H54OSn2
Molecular Weight	596.105
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants.	2016-07	26314263
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.	2015-12	25270620
Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens.	2015-08-17	26198647
Transcriptome-based functional classifiers for direct immunotoxicity.	2014-03	24356939
DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells.	2014-01-30	24247028
Toxicogenomics-based identification of mechanisms for direct immunotoxicity.	2013-10	23824090
Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics.	2013-02-13	23253260
Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells.	2012-07-20	22613032
Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO).	2012-06-14	22434021
Phosphoproteomic analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways.	2012-03	22174045
Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis.	2011-08-01	21601586
The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.	2009-11	21784029
Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).	2009-09	19552622
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening.	2008-01-01	17942131
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats.	2007-09-24	17669578
In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.	2007-07-31	17553608
Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination.	2007-07-15	17599374
Molecular and histological evaluation of tributyltin toxicity on spermatogenesis in a marine fish, the mummichog (Fundulus heteroclitus).	2007-06-05	17451821
Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells.	2007-04	17218080
Gene expression profiling of Bis(tri-n-butyltin)oxide (TBTO)-induced immunotoxicity in mice and rats.	2006-12-01	18958704
Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip").	2005-01-15	15588918
Neurotoxicologic sequelae of tributyltin intoxication in rats.	2002-03	11884216
Toxicology of environmental chemicals in the flounder (Platichthys flesus) with emphasis on the immune system: field, semi-field (mesocosm) and laboratory studies.	2000-03-15	10720744
In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes.	1999-07-01	10454224
Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels.	1998-01	9465272
Acute effect of indoor exposure to paint containing bis(tributyltin) oxide--Wisconsin, 1991.	1991-05-03	2023573
Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests.	1987-06	3108662

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:16:53 GMT 2025` Edited by `admin` on `Mon Mar 31 19:16:53 GMT 2025`
Record UNII	3353Q84MKM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BUTINOX

Preferred Name

English

TRIBUTYLTIN OXIDE

Common Name

English

HEXABUTYLDISTANNOXANE

Systematic Name

English

BIS(TRIBUTYLTIN) OXIDE

Common Name

English

TRIBUTYLTIN OXIDE [HSDB]

Common Name

English

NSC-22332

Code

English

Code System Code Type Description

SMS_ID

300000053676