TRIBUTYLTIN OXIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H54OSn2
Molecular Weight	596.105
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC

InChI

InChIKey=APQHKWPGGHMYKJ-UHFFFAOYSA-N

InChI=1S/6C4H9.O.2Sn/c6*1-3-4-2;;;/h6*1,3-4H2,2H3;;;

HIDE SMILES / InChI

Molecular Formula	C24H54OSn2
Molecular Weight	596.105
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Evaluation of the genetic and embryotoxic effects of bis(tri-n-butyltin)oxide (TBTO), a broad-spectrum pesticide, in multiple in vivo and in vitro short-term tests.	1987 Jun	3108662
Acute effect of indoor exposure to paint containing bis(tributyltin) oxide--Wisconsin, 1991.	1991 May 3	2023573
Effects of in vivo exposure to bis(tri-n-butyltin)oxide, hexachlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA levels in cultured rat splenocytes and on IL-2 receptor protein levels.	1998 Jan	9465272
In vitro exposure effects of cyclosporin A and bis(tri-n-butyltin)oxide on lymphocyte proliferation, cytokine (receptor) mRNA expression, and cell surface marker expression in rat thymocytes and splenocytes.	1999 Jul 1	10454224
Toxicology of environmental chemicals in the flounder (Platichthys flesus) with emphasis on the immune system: field, semi-field (mesocosm) and laboratory studies.	2000 Mar 15	10720744
Neurotoxicologic sequelae of tributyltin intoxication in rats.	2002 Mar	11884216
Detection of immunotoxicity using T-cell based cytokine reporter cell lines ("Cell Chip").	2005 Jan 15	15588918
Gene expression profiling of Bis(tri-n-butyltin)oxide (TBTO)-induced immunotoxicity in mice and rats.	2006 Dec 1	18958704
Effects of various pesticides on human 5alpha-reductase activity in prostate and LNCaP cells.	2007 Apr	17218080
Cytotoxic effects and aromatase inhibition by xenobiotic endocrine disrupters alone and in combination.	2007 Jul 15	17599374
In vitro immunotoxicity of bis(tri-n-butyltin)oxide (TBTO) studied by toxicogenomics.	2007 Jul 31	17553608
Molecular and histological evaluation of tributyltin toxicity on spermatogenesis in a marine fish, the mummichog (Fundulus heteroclitus).	2007 Jun 5	17451821
Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats.	2007 Sep 24	17669578
Overlapping gene expression profiles of model compounds provide opportunities for immunotoxicity screening.	2008 Jan 1	17942131
The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2.	2009 Nov	21784029
Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO).	2009 Sep	19552622
Exposure of Jurkat cells to bis (tri-n-butyltin) oxide (TBTO) induces transcriptomics changes indicative for ER- and oxidative stress, T cell activation and apoptosis.	2011 Aug 1	21601586
Immunocytological and biochemical analysis of the mode of action of bis (tri-n-butyltin) tri-oxide (TBTO) in Jurkat cells.	2012 Jul 20	22613032
Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO).	2012 Jun 14	22434021
Phosphoproteomic analysis of mouse thymoma cells treated with tributyltin oxide: TBTO affects proliferation and energy sensing pathways.	2012 Mar	22174045
Assessment of the usefulness of the murine cytotoxic T cell line CTLL-2 for immunotoxicity screening by transcriptomics.	2013 Feb 13	23253260
Toxicogenomics-based identification of mechanisms for direct immunotoxicity.	2013 Oct	23824090
DON shares a similar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stress patterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in Jurkat T cells.	2014 Jan 30	24247028
Transcriptome-based functional classifiers for direct immunotoxicity.	2014 Mar	24356939
Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens.	2015 Aug 17	26198647
A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.	2015 Dec	25270620
Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants.	2016 Jul	26314263

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:36:51 GMT 2023` Edited by `admin` on `Fri Dec 15 18:36:51 GMT 2023`
Record UNII	3353Q84MKM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIBUTYLTIN OXIDE

Common Name

English

HEXABUTYLDISTANNOXANE

Systematic Name

English

BUTINOX

Brand Name

English

BIS(TRIBUTYLTIN) OXIDE

Common Name

English

TRIBUTYLTIN OXIDE [HSDB]

Common Name

English

NSC-22332

Code

English

Code System Code Type Description

PUBCHEM

13751184