Zamubafusp Alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 17:37:33 GMT 2025` Edited by `admin` on `Wed Apr 02 17:37:33 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	32PJN9JE4A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Zamubafusp Alfa

Official Name

English

Immunoglobulin G1 [54-glutamic acid], anti-(human amyloid fibrils) (human-Mus musculus monoclonal VH9/VL4 ?1-chain), disulfide with [33-serine] human-Mus musculus monoclonal VH9/VL4 ?-chain fusion protein with pan-amyloid-reactive peptide p5R, dimer

Preferred Name

English

zamubafusp alfa [INN]

Common Name

English

humanized immunoglobulin G1-kappa, anti-[human variable immunoglobulin light chain N-terminal cryptic neo-epitope] fused at the C-terminus of each light chain via a peptide linker to the pan-amyloid-reactive peptide p5R

Common Name

English

gamma 1 heavy chain (1-441) [VH (Homo sapiens IGHV4-4*08 -(IGHD) -IGHJ4*01, CDR-Kabat [5.16.3] (31-35.50-65.98-100)) (1-111) -Homo sapiens IGHG1*01 (CH1 (112-209), hinge (210-224), CH2 (225-334), CH3 (335-439), CHS (440-441)) (112-441)], (214-219')-disul

Common Name

English

Code System Code Type Description

FDA UNII

32PJN9JE4A

Created by admin on Wed Apr 02 17:37:33 GMT 2025 , Edited by admin on Wed Apr 02 17:37:33 GMT 2025

PRIMARY

NCI_THESAURUS

C211723

Created by admin on Wed Apr 02 17:37:33 GMT 2025 , Edited by admin on Wed Apr 02 17:37:33 GMT 2025

PRIMARY

INN

13282

Created by admin on Wed Apr 02 17:37:33 GMT 2025 , Edited by admin on Wed Apr 02 17:37:33 GMT 2025

PRIMARY

CAS

2937458-25-6

Created by admin on Wed Apr 02 17:37:33 GMT 2025 , Edited by admin on Wed Apr 02 17:37:33 GMT 2025

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_138	2_194
2_214	4_219
2_255	2_315
1_138	1_194
2_361	2_419
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_214	3_219
1_220	2_220
1_223	2_223
1_255	1_315
1_361	1_419

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_291
N	2_291

Related Record Type Details


					32PJN9JE4A

Zamubafusp Alfa

ACTIVE MOIETY

Comments:

AT-02 is a full-length, humanized, recombinant immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that targets amyloid fibrils

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_441] [2_441]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL