Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H17FN3O4.K |
| Molecular Weight | 409.4527 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[K+].CN1C(=O)C(C(=O)NCCO)=C([O-])C2=NC=C(CC3=CC=C(F)C=C3)C=C12
InChI
InChIKey=KHOKPZJZSBGEPY-UHFFFAOYSA-M
InChI=1S/C19H18FN3O4.K/c1-23-14-9-12(8-11-2-4-13(20)5-3-11)10-22-16(14)17(25)15(19(23)27)18(26)21-6-7-24;/h2-5,9-10,24-25H,6-8H2,1H3,(H,21,26);/q;+1/p-1
| Molecular Formula | C19H17FN3O4 |
| Molecular Weight | 370.3544 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | K |
| Molecular Weight | 39.0983 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
GlaxoSmithKline was developing GSK-364735 as a human immunodeficiency virus (HIV) integrase inhibitor. The inhibition of viral DNA integration takes place by interacting at the two-metal binding site within the catalytic center of HIV integrase. GSK-364735 was successfully studied at Phase II in HIV-infected patients; however, adverse liver effects of GSK364735 were recently observed in a long-term preclinical safety study in the monkey and preclude further development of the compound.
Originator
Approval Year
Sample Use Guides
In part A, three alternating cohorts of 10 subjects (8 receiving the active drug and 2 receiving a placebo) received single doses of 50 to 400 mg while fasting or 200 mg and 400 mg coadministered with food. In part B, five cohorts received repeated doses of 100 to 600 mg daily coadministered with food for 8 days.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 11:31:55 GMT 2023
by
admin
on
Sat Dec 16 11:31:55 GMT 2023
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| Record UNII |
324268A537
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| Record Status |
Validated (UNII)
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| Record Version |
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119025700
Created by
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324268A537
Created by
admin on Sat Dec 16 11:31:55 GMT 2023 , Edited by admin on Sat Dec 16 11:31:55 GMT 2023
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912672-93-6
Created by
admin on Sat Dec 16 11:31:55 GMT 2023 , Edited by admin on Sat Dec 16 11:31:55 GMT 2023
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |