ZINC L-LACTATE

Possibly Marketed Outside US

Details

Stereochemistry	ABSOLUTE
Molecular Formula	2C3H5O3.Zn
Molecular Weight	243.549
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Zn++].C[C@H]([O-])C(O)=O.C[C@H]([O-])C(O)=O

InChI

InChIKey=UHKOOGWQCULNGT-CEOVSRFSSA-N

InChI=1S/2C3H5O3.Zn/c2*1-2(4)3(5)6;/h2*2H,1H3,(H,5,6);/q2*-1;+2/t2*2-;/m00./s1

HIDE SMILES / InChI

Molecular Formula	Zn
Molecular Weight	65.409
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C3H5O3
Molecular Weight	89.07
Charge	-1
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.lactic.com/Portals/0/Brochure/Galactic_Pharma_EN.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26054178

Zinc lactate is used to eliminate halitosis. Halitosis (commonly known as bad breath) is a condition affecting many people and one of the most usual reasons why people go look for a dentist’s advice. The main origin of halitosis is related to the volatile sulphur compounds (VSC) produced by the different bacterial colonies found on the tongue and in the gingival crevices. Zinc lactate is a very effective solution to neutralize the VSC and an excellent ingredient for mouthwashes and toothpastes.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Herpes simplex virus (type 1 / strain F) 3 Target ID: CHEMBL613200 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10790094	Inhibitor 8297
HSV-2 2 Target ID: CHEMBL614731 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10790094	Inhibitor 8297
Gardnerella vaginalis 1 Target ID: CHEMBL614994 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21779311	Inhibitor 8297
Streptococcus mutans 41 Target ID: CHEMBL612426 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17977294	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Halitosis 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28212110 https://www.ncbi.nlm.nih.gov/pubmed/26031397 https://www.ncbi.nlm.nih.gov/pubmed/24693626 https://www.ncbi.nlm.nih.gov/pubmed/12716335 https://www.ncbi.nlm.nih.gov/pubmed/26054178	Primary	Approved 8429	Galanium zinc lactate Approved Use Galanium™ zinc lactate is a perfect solution to eliminate halitosis.
Acne 98 Sources: https://www.drugs.com/otc/397140/clean-and-clear-advantage-acne-control-cleanser.html	Inactive ingredient	Approved 8429	Clean and Clear Advantage Acne Control Cleanser Approved Use Acne treatment
Bacterial vaginosis 10 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21779311	Curative	Basic research	Unknown Approved Use Unknown
Chronic periodontitis 4 Sources: https://clinicaltrials.gov/ct2/show/NCT02875769	Primary	Phase III 656	Unknown Approved Use Unknown
Gingivitis 44 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21269041 https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=54206	Primary	Approved 8429	Crest Pro-Health Clinical Gum Protection Clean Mint Toothpaste Approved Use Anticavity, antigingivitis, antisensitivity toothpaste

PubMed

Title	Date	PubMed
Zinc salts inactivate clinical isolates of herpes simplex virus in vitro.	2000 May	10790094
Effect of different mouthrinses on morning breath.	2001 Sep	11577950
Aggregates and hydrogels prepared by self-assembly of amphiphilic copolymers with surfactants.	2012 May 15	22402181
Dietary zinc deficiency reduced growth performance, intestinal immune and physical barrier functions related to NF-κB, TOR, Nrf2, JNK and MLCK signaling pathway of young grass carp (Ctenopharyngodon idella).	2017 Jul	28549941

Patents

Sample Use Guides

In Vivo Use Guide

The volunteer rinsed with pre-procedural mouthwash containing 0.075% cetylpyridinium chloride, 0.28% zinc lactate and 0.05% sodium fluoride in an Alcohol-free base for one minute, 20 ml of solution and then expectorated all remaining liquid.

Route of Administration: Dental

In Vitro Use Guide

Of 10 randomly chosen clinical isolates of herpes simplex virus (five HSV type 1 [HSV-1] isolates and five HSV-2 isolates), nine were inactivated >97% by treatment with zinc lactate. The effect was concentration dependent. With an HSV-1 isolate, 50 mM zinc lactate caused 100% inactivation, 15 mM caused 98 to 99% inactivation, and 5 mM caused 63 to 86% inactivation. With an HSV-2 isolate, 50 and 15 mM zinc lactate caused greater than 92% inactivation and 5 and 1 mM caused 37 and 26% inactivation, respectively.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:34:05 GMT 2023` Edited by `admin` on `Sat Dec 16 09:34:05 GMT 2023`
Record UNII	323TLL3AFZ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ZINC L-LACTATE

Common Name

English

PROPANOIC ACID, 2-HYDROXY-, ZINC COMPLEX, (S)-

Systematic Name

English

ZINC, BIS((2S)-2-(HYDROXY-.KAPPA.O)PROPANOATO-.KAPPA.O)-, (T-4)-

Systematic Name

English

ZINC, BIS(2-HYDROXYPROPANOATO-O1,O2)-, (T-4-(S),(S))-

Systematic Name

English

Code System Code Type Description

FDA UNII

323TLL3AFZ

Created by admin on Sat Dec 16 09:34:05 GMT 2023 , Edited by admin on Sat Dec 16 09:34:05 GMT 2023

PRIMARY

CAS

63179-81-7

Created by admin on Sat Dec 16 09:34:05 GMT 2023 , Edited by admin on Sat Dec 16 09:34:05 GMT 2023

PRIMARY

PUBCHEM

91667767

Created by admin on Sat Dec 16 09:34:05 GMT 2023 , Edited by admin on Sat Dec 16 09:34:05 GMT 2023

PRIMARY

Details

SMILES

InChI

DescriptionSources: https://www.lactic.com/Portals/0/Brochure/Galactic_Pharma_EN.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26054178

Approval Year

Targets

Conditions

Approved Use

Approved Use

Approved Use

Approved Use

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.lactic.com/Portals/0/Brochure/Galactic_Pharma_EN.pdf | https://www.ncbi.nlm.nih.gov/pubmed/26054178