THIAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H3NS
Molecular Weight	85.128
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

S1C=CN=C1

InChI

InChIKey=FZWLAAWBMGSTSO-UHFFFAOYSA-N

InChI=1S/C3H3NS/c1-2-5-3-4-1/h1-3H

HIDE SMILES / InChI

Molecular Formula	C3H3NS
Molecular Weight	85.128
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Linked parallel synthesis and MTT bioassay screening of substituted chalcones.	2001-09-11	11549359
Role of kainate receptor activation and desensitization on the [Ca(2+)](i) changes in cultured rat hippocampal neurons.	2001-09-01	11536320
Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.	2001-09	11504787
Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function.	2001-09	11494039
PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.	2001-09	11494023
Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism.	2001-08-28	11513588
Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression.	2001-08-17	11500053
The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins.	2001-08-11	11497289
Antineoplastic activity of novel N-1-sulfonypyrimidine derivatives.	2001-08-11	11497287
Influence of extracellular pH on the cytotoxicity and DNA damage of a series of indolequinone compounds.	2001-08-11	11497261
Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.	2001-08-11	11497260
Bone morphogenetic protein-2 and type IV collagen expression in psammoma body forming ovarian cancer.	2001-08-11	11497252
PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells.	2001-08-11	11497245
Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine.	2001-08-03	11482767
Chloroaluminum phthalocyanine tetrasulfonate delivered via acid-labile diplasmenylcholine-folate liposomes: intracellular localization and synergistic phototoxicity.	2001-08-01	11433404
Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells.	2001-08	11534770
Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors.	2001-08	11504640
Follicular stage-dependent tumor necrosis factor alpha-induced hen granulosa cell integrin production and survival in the presence of transforming growth factor alpha in vitro.	2001-08	11466216
On the transformation behaviour, mechanical properties and biocompatibility of two niti-based shape memory alloys: NiTi42 and NiTi42Cu7.	2001-08	11432595
Thiazole orange-positive platelets in healthy and thrombocytopenic dogs.	2001-07-28	11504206
Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress.	2001-07-01	11425492
Metal-induced hormesis requires cPKC-dependent glucose transport and lowered respiration.	2001-07	11530833
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.	2001-07	11498774
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.	2001-07	11473410
Metal complexes of antibiotic drugs. Studies on dicluxacillin complexes of FeII, FeIII, CoII NiII and CuII.	2001-07	11471717
The effect of methyl methanesulfonate (MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells.	2001-07	11458984
4-Acetyl-12,13-epoxyl-9-trichothecene-3,15-diol isolated from the fruiting bodies of Isariajaponica Yasuda induces apoptosis of human leukemia cells (HL-60).	2001-07	11456118
Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells.	2001-07	11408926
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.	2001-06-27	11414820
Organotins disrupt components of glutamate homeostasis in rat astrocyte cultures.	2001-06-22	11437060
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.	2001-06-22	11403956
Calcipotriol inhibits autocrine phosphorylation of EGF receptor in a calcium-dependent manner, a possible mechanism for its inhibition of cell proliferation and stimulation of cell differentiation.	2001-06-08	11394895
Flow cytometric method for simultaneous assay of foetal haemoglobin containing red cells, reticulocytes and foetal haemoglobin containing reticulocytes.	2001-06	11553054
Interactions of cyanine dyes with nucleic acids. XXIV. Aggregation of monomethine cyanine dyes in presence of DNA and its manifestation in absorption and fluorescence spectra.	2001-06	11446704
Inhibition of human DNA topoisomerase I by new DNA minor groove ligands: derivatives of oligo-1,3-thiazolecarboxamides.	2001-06	11446589
The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.	2001-06	11410497
Neoadjuvant chemotherapy in inoperable, locally advanced, and inflammatory breast carcinoma: a pilot study of MTT assay in vitro and outcome analysis of 10 patients.	2001-06	11404497
Nostocyclamide M: a cyanobacterial cyclic peptide with allelopathic activity from Nostoc 31.	2001-06	11394868
Induction of apoptosis by the marine sponge (Mycale) metabolites, mycalamide A and pateamine.	2001-06	11388670
Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons.	2001-05-15	11470319
Cisplatin chemotherapy plus adenoviral p53 gene therapy in EBV-positive and -negative nasopharyngeal carcinoma.	2001-05	11477455
Expression of multidrug resistance-associated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a novel aldose reductase inhibitor.	2001-05	11465409
Cytotoxicity testing with three-dimensional cultures of transfected pulp-derived cells.	2001-04	11485263
Prodigiosin-induced apoptosis in human colon cancer cells.	2001-03-16	11388704
Suppression of matrix metalloproteinase-2 and -9 mediated invasiveness by a novel matrix metalloproteinase inhibitor, BE16627B.	2001-03	11451198
Remarkable synthesis of 2-(Z)-6-(E)-4H-[1,4]-thiazepin-5-ones by zwitteronic rhodium-catalyzed chemo- and regioselective cyclohyrocarbonylative ring expansion of acetylenic thiazoles.	2001-02-14	11456654
Free-probe fluorescence of light-up probes.	2001-02-07	11456613
Dentin barrier test with transfected bovine pulp-derived cells.	2001-02	11491647
In silico discovery of novel retinoic acid receptor agonist structures.	2001	11405897
Modulation of intracellular calcium and proliferative activity of invertebrate and vertebrate cells by ethylene.	2001	11401726

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:47:03 GMT 2025` Edited by `admin` on `Mon Mar 31 18:47:03 GMT 2025`
Record UNII	320RCW8PEF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAZOLE

Systematic Name

English

FEMA NO. 3615

Preferred Name

English

THIAZOLE [FHFI]

Common Name

English

THIAZOLE [MI]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

THIAZOLE