THIAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C3H3NS
Molecular Weight	85.128
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

S1C=CN=C1

InChI

InChIKey=FZWLAAWBMGSTSO-UHFFFAOYSA-N

InChI=1S/C3H3NS/c1-2-5-3-4-1/h1-3H

HIDE SMILES / InChI

Molecular Formula	C3H3NS
Molecular Weight	85.128
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
In silico discovery of novel retinoic acid receptor agonist structures.	2001	11405897
Cytotoxicity testing with three-dimensional cultures of transfected pulp-derived cells.	2001 Apr	11485263
Activation of protein kinase A and atypical protein kinase C by A(2A) adenosine receptors antagonizes apoptosis due to serum deprivation in PC12 cells.	2001 Apr 27	11278423
Inhibition of invasion and induction of apoptosis by curcumin in H-ras-transformed MCF10A human breast epithelial cells.	2001 Aug	11534770
Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors.	2001 Aug	11504640
Follicular stage-dependent tumor necrosis factor alpha-induced hen granulosa cell integrin production and survival in the presence of transforming growth factor alpha in vitro.	2001 Aug	11466216
On the transformation behaviour, mechanical properties and biocompatibility of two niti-based shape memory alloys: NiTi42 and NiTi42Cu7.	2001 Aug	11432595
Chloroaluminum phthalocyanine tetrasulfonate delivered via acid-labile diplasmenylcholine-folate liposomes: intracellular localization and synergistic phototoxicity.	2001 Aug 1	11433404
Reversal of cisplatin and multidrug resistance by ribozyme-mediated glutathione suppression.	2001 Aug 17	11500053
Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism.	2001 Aug 28	11513588
Dentin barrier test with transfected bovine pulp-derived cells.	2001 Feb	11491647
Remarkable synthesis of 2-(Z)-6-(E)-4H-[1,4]-thiazepin-5-ones by zwitteronic rhodium-catalyzed chemo- and regioselective cyclohyrocarbonylative ring expansion of acetylenic thiazoles.	2001 Feb 14	11456654
Free-probe fluorescence of light-up probes.	2001 Feb 7	11456613
Metal-induced hormesis requires cPKC-dependent glucose transport and lowered respiration.	2001 Jul	11530833
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.	2001 Jul	11498774
New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.	2001 Jul	11473410
Metal complexes of antibiotic drugs. Studies on dicluxacillin complexes of FeII, FeIII, CoII NiII and CuII.	2001 Jul	11471717
The effect of methyl methanesulfonate (MMS)-induced excision repair on p53-dependent apoptosis in human lymphoid cells.	2001 Jul	11458984
4-Acetyl-12,13-epoxyl-9-trichothecene-3,15-diol isolated from the fruiting bodies of Isariajaponica Yasuda induces apoptosis of human leukemia cells (HL-60).	2001 Jul	11456118
Trans-resveratrol, a grapevine-derived polyphenol, blocks hepatocyte growth factor-induced invasion of hepatocellular carcinoma cells.	2001 Jul	11408926
Expression of glutathione-S-transferase isozyme in the SY5Y neuroblastoma cell line increases resistance to oxidative stress.	2001 Jul 1	11425492
Thiazole orange-positive platelets in healthy and thrombocytopenic dogs.	2001 Jul 28	11504206
Flow cytometric method for simultaneous assay of foetal haemoglobin containing red cells, reticulocytes and foetal haemoglobin containing reticulocytes.	2001 Jun	11553054
Interactions of cyanine dyes with nucleic acids. XXIV. Aggregation of monomethine cyanine dyes in presence of DNA and its manifestation in absorption and fluorescence spectra.	2001 Jun	11446704
Inhibition of human DNA topoisomerase I by new DNA minor groove ligands: derivatives of oligo-1,3-thiazolecarboxamides.	2001 Jun	11446589
The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel.	2001 Jun	11410497
Neoadjuvant chemotherapy in inoperable, locally advanced, and inflammatory breast carcinoma: a pilot study of MTT assay in vitro and outcome analysis of 10 patients.	2001 Jun	11404497
Organotins disrupt components of glutamate homeostasis in rat astrocyte cultures.	2001 Jun 22	11437060
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.	2001 Jun 22	11403956
A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.	2001 Jun 27	11414820
Suppression of matrix metalloproteinase-2 and -9 mediated invasiveness by a novel matrix metalloproteinase inhibitor, BE16627B.	2001 Mar	11451198
Thrombin-stimulated growth, clustering, and collagen lattice contraction of human gingival fibroblasts is associated with its protease activity.	2001 Mar	11327057
Silencing of the caspase-1 gene occurs in murine and human renal cancer cells and causes solid tumor growth in vivo.	2001 Mar 1	11267979
t-Butyl hydroperoxide and oxidized low density lipoprotein enhance phospholipid hydrolysis in lipopolysaccharide-stimulated retinal pericytes.	2001 Mar 30	11278179
Cisplatin chemotherapy plus adenoviral p53 gene therapy in EBV-positive and -negative nasopharyngeal carcinoma.	2001 May	11477455
Expression of multidrug resistance-associated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a novel aldose reductase inhibitor.	2001 May	11465409
Manganese toxicity is associated with mitochondrial dysfunction and DNA fragmentation in rat primary striatal neurons.	2001 May 15	11470319
CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and Fas expression and proliferation of human non-small cell lung tumors.	2001 May 15	11304696
Cytotoxicity evaluation of natural coptisine and synthesis of coptisine from berberine.	2001 May-Jul	11482767
The carcinostatic and proapoptotic potential of 4-hydroxynonenal in HeLa cells is associated with its conjugation to cellular proteins.	2001 May-Jun	11497289
Antineoplastic activity of novel N-1-sulfonypyrimidine derivatives.	2001 May-Jun	11497287
Influence of extracellular pH on the cytotoxicity and DNA damage of a series of indolequinone compounds.	2001 May-Jun	11497261
Irofulven (6-hydroxymethylacylfulvene, MGI 114) induces caspase 8 and 9-mediated apoptosis in human pancreatic adenocarcinoma cells.	2001 May-Jun	11497260
Bone morphogenetic protein-2 and type IV collagen expression in psammoma body forming ovarian cancer.	2001 May-Jun	11497252
PM-3, a benzo-gamma-pyran derivative isolated from propolis, inhibits growth of MCF-7 human breast cancer cells.	2001 May-Jun	11497245
Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2'-O-(2-methoxy)ethyl chemistry.	2001 Sep	11504787
Effects of tetramethylpiperidine (TMP)-substituted phenazines on membrane stability and P-glycoprotein function.	2001 Sep	11494039
PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity.	2001 Sep	11494023
Role of kainate receptor activation and desensitization on the [Ca(2+)](i) changes in cultured rat hippocampal neurons.	2001 Sep 1	11536320
Linked parallel synthesis and MTT bioassay screening of substituted chalcones.	2001 Sep-Oct	11549359

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:28:15 GMT 2023` Edited by `admin` on `Fri Dec 15 17:28:15 GMT 2023`
Record UNII	320RCW8PEF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THIAZOLE

Systematic Name

English

FEMA NO. 3615

Code

English

THIAZOLE [FHFI]

Common Name

English

THIAZOLE [MI]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

THIAZOLE