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Details

Stereochemistry ACHIRAL
Molecular Formula CH4N2O.H2O2
Molecular Weight 94.0699
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CARBAMIDE PEROXIDE

SMILES

OO.NC(N)=O

InChI

InChIKey=AQLJVWUFPCUVLO-UHFFFAOYSA-N
InChI=1S/CH4N2O.H2O2/c2-1(3)4;1-2/h(H4,2,3,4);1-2H

HIDE SMILES / InChI
Molecular Formula CH4N2O
Molecular Weight 60.0553
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula H2O2
Molecular Weight 34.0147
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

CNS Activity

Originator

Approval Year

1921
1467
Targets

Targets

Primary TargetPharmacologyConditionPotency
Modulator
828
Agonist
2678
 4.54 null [pEC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8429
ESKATA

Approved Use

ESKATA is indicated for the treatment of seborrheic keratoses that are raised.

Launch Date

1.51312322E12
Preventing
Approved
8429
Hydrogen Peroxide Solution

Approved Use

Uses of Hydrogen Peroxide Solution: It is used to prevent skin infections. It is used to help get rid of phlegm or mucus or help with a sore mouth.
Primary
Approved
8429
Hydrogen Peroxide Solution

Approved Use

Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis).

Launch Date

4.10140803E11
PubMed

PubMed

TitleDatePubMed
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide.
1999 Jul 1
Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress.
2000 Mar
Involvement of lipoxygenase in lysophosphatidic acid-stimulated hydrogen peroxide release in human HaCaT keratinocytes.
2000 Mar 15
The super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL.
2000 Nov 24
Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia.
2000 Oct
Roles of oxygen radical production and lipid peroxidation in the cytotoxicity of cephaloridine on cultured renal epithelial cells (LLC-PK1).
2000 Sep
Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways.
2000 Sep
Phospholipase D2 activity suppresses hydrogen peroxide-induced apoptosis in PC12 cells.
2000 Sep
Simultaneous measurement of ERK, p38, and JNK MAP kinase cascades in vascular smooth muscle cells.
2000 Sep-Oct
Mitochondrial-derived oxidants and quartz activation of chemokine gene expression.
2001
Repression of GADD153/CHOP by NF-kappaB: a possible cellular defense against endoplasmic reticulum stress-induced cell death.
2001 Apr 19
Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation.
2001 Apr 27
Reactive carbonyl formation by oxidative and non-oxidative pathways.
2001 Aug 1
Thioredoxin peroxidase-1 (peroxiredoxin-1) is increased in thioredoxin-1 transfected cells and results in enhanced protection against apoptosis caused by hydrogen peroxide but not by other agents including dexamethasone, etoposide, and doxorubicin.
2001 Aug 1
NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells.
2001 Dec 1
Repression of phenobarbital-dependent CYP2B1 mRNA induction by reactive oxygen species in primary rat hepatocyte cultures.
2001 Jun
Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein.
2001 Nov 30
Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells.
2001 Oct
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
2001 Oct
Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes.
2002 Apr
High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells.
2002 Aug
Overexpression of copper zinc superoxide dismutase suppresses human glioma cell growth.
2002 Feb 15
Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts.
2002 Jul
Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.
2002 Jul 15
Reversible inactivation of the tumor suppressor PTEN by H2O2.
2002 Jun 7
Glucose-6-phosphate dehydrogenase: the key to sex-related xenobiotic toxicity in hepatocytes of European flounder (Platichthys flesus L.)?
2002 Mar
Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
2002 May
Differential expression of two stress-inducible hsp70 genes by various stressors.
2002 May 31
Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species.
2002 Oct
Iron augments stage-I and stage-II tumor promotion in murine skin.
2002 Sep 26
The antioxidant cocktail effective microorganism X (EM-X) inhibits oxidant-induced interleukin-8 release and the peroxidation of phospholipids in vitro.
2002 Sep 6
Patents

Patents

03931169
4
03932472
94
03947406
32
03952001
6
03985796
4
04007276
7
04012430
5
04022769
14
04023926
4
04028278
4
04036988
4
04039685
4
04042773
4
04062875
4
04064135
4
04083983
6
04098816
16
04100280
5
04115584
8
04148918
8
04153716
4
04163789
5
04168379
7
04170704
9
04172945
10
04180518
6
20040162406
4
6639031
4

Sample Use Guides

In Vivo Use Guide
Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session.
Route of Administration: Topical
In Vitro Use Guide
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
Substance Class Chemical
Created
by admin
on Sat Dec 16 19:57:40 UTC 2023
Edited
by admin
on Sat Dec 16 19:57:40 UTC 2023
Record UNII
31PZ2VAU81
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CARBAMIDE PEROXIDE
MI   USP   VANDF  
Common Name English
CARBAMIDE PEROXIDE [MI]
Common Name English
Urea hydrogen peroxide [WHO-DD]
Common Name English
MURINE EAR DROPS
Brand Name English
UREA HYDROGEN PEROXIDE
MART.   WHO-DD  
Systematic Name English
CARBAMIDE PEROXIDE [USP MONOGRAPH]
Common Name English
UREA HYDROGEN PEROXIDE [MART.]
Common Name English
CARBAMIDE PEROXIDE [VANDF]
Common Name English
UREA PEROXIDE
INCI  
INCI  
Official Name English
NSC-24852
Code English
UREA HYDROGEN PEROXIDE (1:1)
Systematic Name English
UREA, COMPD. WITH HYDROGEN PEROXIDE (1:1)
Systematic Name English
UREA PEROXIDE [INCI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
CFR 21 CFR 344.10
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
Code System Code Type Description
MESH
C009096
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
EPA CompTox
DTXSID9024726
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
EVMPD
SUB15664MIG
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
NSC
24852
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
DRUG CENTRAL
4445
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
RXCUI
47686
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY RxNorm
NCI_THESAURUS
C77033
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
ECHA (EC/EINECS)
204-701-4
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
WIKIPEDIA
Hydrogen peroxide - urea
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
LACTMED
Carbamide Peroxide
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
CHEBI
75178
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
CAS
124-43-6
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
FDA UNII
31PZ2VAU81
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
DAILYMED
31PZ2VAU81
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
DRUG BANK
DB11129
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
MERCK INDEX
m3054
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY Merck Index
SMS_ID
100000088234
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
PUBCHEM
31294
Created by admin on Sat Dec 16 19:57:40 UTC 2023 , Edited by admin on Sat Dec 16 19:57:40 UTC 2023
PRIMARY
Related Record Type Details
Structure of Hydrogen peroxide
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