REVAMILAST

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H9Cl2F2N3O4
Molecular Weight	440.185
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[O-][N+]1=CC(Cl)=C(NC(=O)C2=CC=C(OC(F)F)C3=C2C4=CN=CC=C4O3)C(Cl)=C1

InChI

InChIKey=IXQHNBONEVULTL-UHFFFAOYSA-N

InChI=1S/C18H9Cl2F2N3O4/c19-10-6-25(27)7-11(20)15(10)24-17(26)8-1-2-13(29-18(21)22)16-14(8)9-5-23-4-3-12(9)28-16/h1-7,18H,(H,24,26)

HIDE SMILES / InChI

Molecular Formula	C18H9Cl2F2N3O4
Molecular Weight	440.185
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.drugbank.ca/drugs/DB11838 | https://clinicaltrials.gov/ct2/show/NCT01436890 | https://clinicaltrials.gov/ct2/show/NCT01430507 | https://www.prnewswire.com/news-releases/glenmark-initiates-phase-iib-human-trials-globally-for-its-novel-molecule-revamilast-127442178.html

Revamilast is an orally active, potent and selective phosphodiesterase 4 (PDE 4) inhibitor that is being studied for its potential in treatment of inflammatory disorders. PDE 4 inhibitors attenuate the inflammatory response and suppress many cytokines, including TNF-α production in mononuclear cells. Initial studies showed no serious adverse events in healthy volunteers and phase II studies have evaluated the effect of revamilast on long function and rheumatoid arthritis.

Originator

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:28:35 GMT 2023` Edited by `admin` on `Sat Dec 16 17:28:35 GMT 2023`
Record UNII	30LE65637T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

REVAMILAST

Official Name

English

3,5-DICHLORO-4-((6-(DIFLUOROMETHOXY)(1)BENZOFURO(3,2-C)PYRIDINE-9-YL)CARBOXAMIDO)PYRIDINE 1-OXIDE

Common Name

English

Revamilast [WHO-DD]

Common Name

English

revamilast [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744