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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H21NO2.ClH
Molecular Weight 307.815
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NISOXETINE HYDROCHLORIDE, (-)-

SMILES

Cl.CNCC[C@H](OC1=C(OC)C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=LCEURBZEQJZUPV-RSAXXLAASA-N
InChI=1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H/t15-;/m0./s1

HIDE SMILES / InChI
Molecular Formula C17H21NO2
Molecular Weight 271.3541
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

There is not much information related to the S isomer of nisoxetine. It is known, that (S)-nisoxetine is 20 times less active than R-enantiomer. And that racemic nisoxetine currently doesn’t have any clinical application in spite of had been researched as an antidepressant.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain.
1995 Jun
Patents

Patents

20070010678
4

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 00:41:47 GMT 2023
Edited
by admin
on Sat Dec 16 00:41:47 GMT 2023
Record UNII
30807965UW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
NISOXETINE HYDROCHLORIDE, (-)-
Common Name English
BENZENEPROPANAMINE, .GAMMA.-(2-METHOXYPHENOXY)-N-METHYL-, HYDROCHLORIDE, (S)-
Systematic Name English
(S)-NISOXETINE HYDROCHLORIDE
Common Name English
(S)-(-)-NISOXETINE HYDROCHLORIDE
Common Name English
Code System Code Type Description
FDA UNII
30807965UW
Created by admin on Sat Dec 16 00:41:47 GMT 2023 , Edited by admin on Sat Dec 16 00:41:47 GMT 2023
PRIMARY
CAS
114446-54-7
Created by admin on Sat Dec 16 00:41:47 GMT 2023 , Edited by admin on Sat Dec 16 00:41:47 GMT 2023
PRIMARY
PUBCHEM
12807464
Created by admin on Sat Dec 16 00:41:47 GMT 2023 , Edited by admin on Sat Dec 16 00:41:47 GMT 2023
PRIMARY
NIH
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