CINITAPRIDE TARTRATE

Details

Stereochemistry	EPIMERIC
Molecular Formula	C21H30N4O4.C4H6O6
Molecular Weight	552.5741
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CCOC1=C(C=C(C(N)=C1)[N+]([O-])=O)C(=O)NC2CCN(CC3CCC=CC3)CC2

InChI

InChIKey=HVANMRCHFMTSEG-LREBCSMRSA-N

InChI=1S/C21H30N4O4.C4H6O6/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15;5-1(3(7)8)2(6)4(9)10/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1

HIDE SMILES / InChI

Molecular Formula	C4H6O6
Molecular Weight	150.0868
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C21H30N4O4
Molecular Weight	402.4873
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9211565 | https://scopeheal.com/cinitapride/

Cinitapride is an agonist of 5-HT4 and 5-HT1 receptors and antagonist of 5-HT2 receptors. Cinitapride is marketed worldwide for the treatment of gastrointestinal disorders related to motility such as indigestion or functional or non-ulcer dyspepsia, gastroesophageal reflux diseases, delay in gastric emptying and vomiting.

Approval Year

PubMed

Title	Date	PubMed
[Efficacy and tolerance of cinitapride on the disturbances of gastrointestinal transit].	1991 Jul-Sep	1820589
[Cinitapride in the treatment of gastroesophageal reflux. Comparative study with metoclopramide and placebo].	1992 Jan-Mar	1626164
[Metoclopramide versus cinitapride in the treatment of functional dyspepsia].	1993 Jul	8218764
Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds.	1997 Apr	9211565
Effects of cinitapride on gastric ulceration and secretion in rats.	1998 Mar	9562338
[Prokinetic agents as a cause of granulomatous interstitial nephritis].	2007 Dec	18028853
The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole.	2007 Jul	17437965
[Efficacy and tolerability of cinitapride in the treatment of functional dyspepsia and delayed gastric emptying].	2009 Dec	19819042

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:46:11 GMT 2023` Edited by `admin` on `Sat Dec 16 09:46:11 GMT 2023`
Record UNII	2Z90GEN540
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CINITAPRIDE TARTRATE

Common Name

English

BENZAMIDE, 4-AMINO-N-(1-(3-CYCLOHEXEN-1-YLMETHYL)-4-PIPERIDINYL)-2-ETHOXY-5-NITRO-, (2R,3R)-2,3-DIHYDROXYBUTANEDIOATE (1:1)

Systematic Name

English

Cinitapride tartrate [WHO-DD]

Common Name

English

CIDINE

Brand Name

English

CINITAPRIDE TARTRATE [MI]

Common Name

English

LAS-17177

Code

English

Code System Code Type Description

SMS_ID

100000090189