Tecotabart

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:28:58 GMT 2025` Edited by `admin` on `Wed Apr 02 11:28:58 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	2X6PWL75TG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tecotabart

Common Name

English

LM-102

Preferred Name

English

Immunoglobulin G1 [241-aspartic acid,334-glutamic acid], anti-(human/Mus musculus/Macaca/Rattus claudin CLDN18.2) (human-Mus musculus monoclonal LM-102 ?1-chain), disulfide with human-Mus musculus monoclonal LM-102 ?-chain, dimer

Common Name

English

tecotabart [INN]

Common Name

English

H-gamma1 heavy chain humanized (1-449) [VH (Homo sapiens IGHV3-48*01 (88.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119) -Homo sapiens IGHG1*01, G1m17,1 CH1 K120, CH3 D12, L14, G1v7 CH2 D3, E117 (CH1 K120 (216) (120-217), hi

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens CLDN18 (claudin 18, claudin-18, surfactant associated protein J, SFTPJ)], humanized monoclonal antibody (tecotabart )

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C183147

Created by admin on Wed Apr 02 11:28:58 GMT 2025 , Edited by admin on Wed Apr 02 11:28:58 GMT 2025

PRIMARY

CAS

2823329-10-6

Created by admin on Wed Apr 02 11:28:58 GMT 2025 , Edited by admin on Wed Apr 02 11:28:58 GMT 2025

PRIMARY

INN

13031

Created by admin on Wed Apr 02 11:28:58 GMT 2025 , Edited by admin on Wed Apr 02 11:28:58 GMT 2025

PRIMARY

SMS_ID

300000054772

Created by admin on Wed Apr 02 11:28:58 GMT 2025 , Edited by admin on Wed Apr 02 11:28:58 GMT 2025

PRIMARY

FDA UNII

2X6PWL75TG

Created by admin on Wed Apr 02 11:28:58 GMT 2025 , Edited by admin on Wed Apr 02 11:28:58 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_146	2_202
2_222	4_220
2_263	2_323
1_146	1_202
2_369	2_427
3_23	3_94
3_140	3_200
4_23	4_94
4_140	4_200
1_222	3_220
1_228	2_228
1_231	2_231
1_263	1_323
1_369	1_427

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_299
N	2_299

Related Record Type Details


					2X6PWL75TG

ACTIVE MOIETY

Comments:

after binding, it can inhibit the spread of tumor cells, effectively kill Claudin18.2-positive tumor cells by triggering antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), directly induce apoptosis and inhibit the proliferation of tumor cells by activating FcR receptor-positive cells and complement factors, so as to achieve anti-tumor effects.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_449] [2_449]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL