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Details

Stereochemistry ACHIRAL
Molecular Formula C5H4N2O2
Molecular Weight 124.0975
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRAZINOIC ACID

SMILES

OC(=O)C1=NC=CN=C1

InChI

InChIKey=NIPZZXUFJPQHNH-UHFFFAOYSA-N
InChI=1S/C5H4N2O2/c8-5(9)4-3-6-1-2-7-4/h1-3H,(H,8,9)

HIDE SMILES / InChI

Molecular Formula C5H4N2O2
Molecular Weight 124.0975
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
Antimycobacterial activity of a series of pyrazinoic acid esters.
1992 Apr 3
A new packing variant of catena-poly[[aquachlorocopper(II)]-mu-pyrazine-2-carboxylato-O,N:N'].
2001 Dec
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
2001 Jan 22
Recurrence of carboxylic acid-pyridine supramolecular synthon in the crystal structures of some pyrazinecarboxylic acids.
2002 Jan 25
Anaerobic incubation conditions enhance pyrazinamide activity against Mycobacterium tuberculosis.
2004 Aug
Function and localization of urate transporter 1 in mouse kidney.
2004 Feb
Self-assembly of diorganotin(IV) moieties and 2-pyrazinecarboxylic acid: syntheses, characterizations and crystal structures of monomeric, polymeric or trinuclear macrocyclic compounds.
2004 Jun 21
Hydrothermal syntheses and structures of two mixed-valence copper(I,II) 2-pyrazinecarboxylate coordination polymers.
2005 May 30
A density functional theory study of the mechanism of free radical generation in the system vanadate/PCA/H2O2.
2005 Sep 29
[Ln2(C2O4)2(pyzc)2(H2O)2]n[Ln = Pr (1), Er (2)]: novel two-dimensional lanthanide coordination polymers with 2-pyrazinecarboxylate and oxalate.
2006 Dec 25
Polar symmetry and intercalation of new multilayered hybrid molybdates: [M2(pzc)2(H2O)x][Mo5O16] (M = Co, Ni).
2006 Jun 12
Substituted pyrazinecarboxamides: synthesis and biological evaluation.
2006 Mar 29
pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates from the southeast region of Brazil.
2006 Nov
Effects of weak acids, UV and proton motive force inhibitors on pyrazinamide activity against Mycobacterium tuberculosis in vitro.
2006 Nov
2'-(3-Hydroxy-benzyl-idene)pyrazine-2-carbohydrazide monohydrate.
2007 Dec 6
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.
2007 Jan
Interpretation of the multiple vanadium-oxygen bonds in the central VO(eta2-O2)+ group. Synthesis, structure, supramolecular interactions and DFT studies for complexes with 2,2'-bipyridine, 1,10-phenanthroline, pyrazinato(1-) and pyrazinamide ligands.
2008 Jan 7
Identification of a new urate and high affinity nicotinate transporter, hOAT10 (SLC22A13).
2008 Jun 13
Diaqua-bis(pyrazine-2-carboxyl-ato-κN,O)manganese(II) dihydrate.
2008 Mar 14
Synthesis and antimycobacterial evaluation of substituted pyrazinecarboxamides.
2008 May
Suppression of blood lipid concentrations by volatile Maillard reaction products.
2008 Nov-Dec
Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans.
2008 Oct 3
Poly[diaqua(μ(2)-oxalato-κO,O:O,O)(μ(2)-pyrazine-2-carboxyl-ato-κN,O:O')cerium(III)].
2008 Sep 20
Poly[bis-(μ(2)-pyrazine-2-carboxyl-ato)-κN,O:O';κN,O:O-cadmium(II)].
2009 Dec 24
Ligand-based modification of the structures and optical properties of new silver(I)-rhenate(VII) oxide/organic hybrid solids.
2009 Dec 7
Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.
2009 Jun 28
A polymorph of diaqua-bis(pyrazine-2-carboxyl-ato-κN,O)copper(II).
2009 Nov 4
Combined Mössbauer spectral and density functional theory determination of the magnetic easy-axis in two high-spin iron(II) 2-pyrazinecarboxylate complexes.
2009 Sep 7
Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.
2010
Poly[aqua-(μ-pyrazine-2-carboxyl-ato-κN,O:O)(μ-pyrazine-2-carboxyl-ato-κN,O:O')lead(II)].
2010 Apr 17
Photoluminescent lanthanide-organic bilayer networks with 2,3-pyrazinedicarboxylate and oxalate.
2010 Apr 5
Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.
2010 Aug
Surveillance of pyrazinamide susceptibility among multidrug-resistant Mycobacterium tuberculosis isolates from Siriraj Hospital, Thailand.
2010 Aug 20
QSAR modeling of a set of pyrazinoate esters as antituberculosis prodrugs.
2010 Feb
Reductive degradation of pyrazine-2-carboxylate by a newly isolated Stenotrophomonas sp. HCU1.
2010 Sep
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
2011 Jun
Patents
Substance Class Chemical
Created
by admin
on Thu Jul 06 02:48:05 UTC 2023
Edited
by admin
on Thu Jul 06 02:48:05 UTC 2023
Record UNII
2WB23298SP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PYRAZINOIC ACID
MI  
Systematic Name English
2-PYRAZINECARBOXYLIC ACID
Systematic Name English
NSC-13146
Code English
PYRAZINOIC ACID [MI]
Common Name English
PYRAZINAMIDE RELATED COMPOUND A [USP-RS]
Common Name English
Code System Code Type Description
RS_ITEM_NUM
1585017
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
ECHA (EC/EINECS)
202-718-1
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
CHEBI
71311
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
CAS
98-97-5
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
NSC
13146
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
EPA CompTox
DTXSID30243367
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
MESH
C005296
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
MERCK INDEX
M9340
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY Merck Index
PUBCHEM
1047
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
WIKIPEDIA
PYRAZINOIC ACID
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
FDA UNII
2WB23298SP
Created by admin on Thu Jul 06 02:48:05 UTC 2023 , Edited by admin on Thu Jul 06 02:48:05 UTC 2023
PRIMARY
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