DIHEXADECYL PHOSPHATE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C32H67O4P
Molecular Weight	546.8457
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC

InChI

InChIKey=RNPXCFINMKSQPQ-UHFFFAOYSA-N

InChI=1S/C32H67O4P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-35-37(33,34)36-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h3-32H2,1-2H3,(H,33,34)

HIDE SMILES / InChI

Molecular Formula	C32H67O4P
Molecular Weight	546.8457
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Pain 619 Sources: http://www.cir-safety.org/sites/default/files/alkpht022014SLR_0.pdf https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ddab62ce-2527-4d0c-969c-738a805cf7cb&type=display	Palliative		Approved 8583	CYHOT Cream with Lidocaine Well at WAlgreens Approved Use Temporarily relieves pain and itching due to: • sunburn • minor burns • minor cuts • scrapes • insect bites Launch Date 2017

PubMed

Title	Date	PubMed
Development of naftifine hydrochloride alcohol-free niosome gel.	2009-05	18989805
The enhancement of immunosuppressive effects of cyclosporine A on human T-cells using fusogenic liposomes.	2008-12-01	18930640
Spin labelling study of interfacial properties of egg-phosphatidylcholine liposomes as a function of cholesterol concentrations.	2008-10	18691564
Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes.	2008-09-01	18577437
Cationic nanoparticles for delivery of amphotericin B: preparation, characterization and activity in vitro.	2008-05-07	18462496
Spontaneous vesicles of sodium dihexadecylphosphate in HEPES buffer.	2008-04-15	18295226
Self-assembly of electroactive layer-by-layer films of heme proteins with anionic surfactant dihexadecyl phosphate.	2008-04	18294752
Effect of charged and non-ionic membrane additives on physicochemical properties and stability of niosomes.	2008	18636334
Optimization of formulation variables of benzocaine liposomes using experimental design.	2008	18569447
Niosome-encapsulated gentamicin for ophthalmic controlled delivery.	2008	18563578
Enhanced transdermal delivery of salbutamol sulfate via ethosomes.	2007-12-14	18181528
Influence of a niosomal formulation on the oral bioavailability of acyclovir in rabbits.	2007-12-14	18181527
Interaction and transport of poly(L-lysine) dendrigrafts through liposomal and cellular membranes: the role of generation and surface functionalization.	2007-10	17880235
Comparative characterization of the physicochemical behavior and skin permeation of extruded DPPC liposomes modified by selected additives.	2007-08	17301964
Immuno-targeting of nonionic surfactant vesicles to inflammation.	2007-07-18	17448616
Fatty alcohols or fatty acids as niosomal hybrid carrier: effect on vesicle size, encapsulation efficiency and in vitro dye release.	2007-07-01	17339104
Preparation of liposomal gene therapy vectors by a scalable method without using volatile solvents or detergents.	2007-05-10	17353061
Study on the electrochemical behavior and differential pulse voltammetric determination of rhein using a nanoparticle composite film-modified electrode.	2007-05	16820331
Direct electrochemistry of glucose oxidase in a colloid Au-dihexadecylphosphate composite film and its application to develop a glucose biosensor.	2007-05	16766233
Preparation of an ion-exchangeable polymer bead wrapped with bilayer membrane structures for high performance liquid chromatography.	2007-04-18	17397656
Ultrasound enhancement of drug release across non ionic surfactant vesicle membranes.	2007-02-03	17271051
Liposomes and niosomes as potential carriers for dermal delivery of minoxidil.	2007-02	17365280
Skin permeation enhancement of ascorbyl palmitate by liposomal hydrogel (lipogel) formulation and electrical assistance.	2007-02	17268089
In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin.	2007-01-10	16997517
Liposomes as an ocular delivery system for acetazolamide: in vitro and in vivo studies.	2007-01-05	17408209
In vitro evaluation of enrofloxacin-loaded MLV liposomes.	2007-01	17107930
Microscopical investigations of nisin-loaded nanoliposomes prepared by Mozafari method and their bacterial targeting.	2007	17689087
Modeling cell membrane transport: interaction of guanidinylated poly(propylene imine) dendrimers with a liposomal membrane consisting of phosphate-based lipids.	2006-12-19	17154621
Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration.	2006-11	17090399
Ion distributions at charged aqueous surfaces by near-resonance X-ray spectroscopy.	2006-11	17057322
Enhancement of follicular delivery of finasteride by liposomes and niosomes 1. In vitro permeation and in vivo deposition studies using hamster flank and ear models.	2006-10-12	16837150
Tuberculosis chemotherapy: current drug delivery approaches.	2006-09-19	16984627
Influence of particle size on drug delivery to rat alveolar macrophages following pulmonary administration of ciprofloxacin incorporated into liposomes.	2006-09	17043040
Uptake of dexamethasone incorporated into liposomes by macrophages and foam cells and its inhibitory effect on cellular cholesterol ester accumulation.	2006-09	16945180
Electrochemical determination of 2-chlorophenol using an acetylene black film modified glassy carbon electrode.	2006-09	16901529
Action mechanism of water soluble ethanol on phospholipid monolayers using a quartz crystal oscillator.	2006-06-15	16413028
Electrochemical study of lincomycin on a multi-wall carbon nanotubes modified glassy carbon electrode and its determination in tablets.	2006-06-07	16503106
Electrochemistry and voltammetric determination of colchicine using an acetylene black-dihexadecyl hydrogen phosphate composite film modified glassy carbon electrode.	2006-05	16122990
A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network.	2006-03-27	16446064
Niosomes as carriers for tretinoin. III. A study into the in vitro cutaneous delivery of vesicle-incorporated tretinoin.	2006-03-27	16439071
Enhancement of the transdermal delivery of catechins by liposomes incorporating anionic surfactants and ethanol.	2006-03-09	16413711
ATP-dependent and drug-inhibited vesicle enlargement reconstituted using synthetic lipids and recombinant proteins.	2006	17379941
Colloid stability of sodium dihexadecyl phosphate/poly(diallyldimethylammonium chloride) decorated latex.	2005-10-11	16207027
Synthesis and biological evaluation of spin-labeled alkylphospholipid analogs.	2005-10-06	16190765
Effect of charge and lipid concentration on in-vivo percutaneous absorption of methyl nicotinate from liposomal vesicles.	2005-09	16105237
Interaction of functional dendrimers with multilamellar liposomes: design of a model system for studying drug delivery.	2005-08-02	16042483
Structure and temperature behavior of metallo-supramolecular assemblies.	2005-07-07	16852587
Application of protein-coupled liposomes to effective affinity screening from phage library.	2005-07-01	16013611
Efficient drug delivery to atherosclerotic lesions and the antiatherosclerotic effect by dexamethasone incorporated into liposomes in atherogenic mice.	2005-05	16051539
Determination of vesicle-water partition coefficients by electrokinetic chromatography: study of temperature effect.	2002-09-15	16290870

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 17:56:59 GMT 2025` Edited by `admin` on `Wed Apr 02 17:56:59 GMT 2025`
Record UNII	2V6E5WN99N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIHEXADECYL PHOSPHATE

Systematic Name

English

DICETYL PHOSPHATE

Preferred Name

English

NSC-12429

Code

English

DICETYLPHOSPHATE

Systematic Name

English

Code System Code Type Description

CHEBI

60424