DIZOCILPINE, (-)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H15N
Molecular Weight	221.297
Optical Activity	( - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@]12N[C@@H](CC3=CC=CC=C13)C4=CC=CC=C24

InChI

InChIKey=LBOJYSIDWZQNJS-JKSUJKDBSA-N

InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15-,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H15N
Molecular Weight	221.297
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Voltage-gated potassium channel 17 Target ID: CHEMBL2362996 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25704024	Blocker 555		134.0 µM [IC50]
Glutamate NMDA receptor 47 Target ID: CHEMBL1907608 Sources: https://www.ncbi.nlm.nih.gov/pubmed/3529096	Antagonist 2849		211.7 nM [Ki]

PubMed

Title	Date	PubMed
Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.	2010-03	20026674
Pharmacological characterization of harmaline-induced tremor activity in mice.	2009-08-15	19497322
Input-specific plasticity of N-methyl-D-aspartate receptor-mediated synaptic responses in neonatal rat motoneurons.	2009-06	19490018
Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder.	2008-05-31	18423440
Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor.	2008-05-31	18378225
Activation of spinal ERK signaling pathway contributes to pain-related responses induced by scorpion Buthus martensi Karch venom.	2008-05	18328523
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors.	2008-02-26	18155693
Effects of selective inhibition of N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) on mice in learning and memory tasks.	2008-01-28	18031726
ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models.	2007-08	17519387
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.	2007-08	17502428
Risperidone attenuates MK-801-induced hyperlocomotion in mice via the blockade of serotonin 5-HT 2A/2C receptors.	2007-06-14	17395179
N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists suppress the superior sagittal sinus-evoked activity of C1 spinal neurons responding to tooth pulp electrical stimulation in rats.	2006-09	16998614
The nicotinic agonist RJR-2403 compensates the impairment of eyeblink conditioning produced by the noncompetitive NMDA-receptor antagonist MK-801.	2006-07-10	16644113
Protection of amyloid beta protein (25-35)-induced neurotoxicity by methanol extract of Smilacis chinae rhizome in cultured rat cortical neurons.	2006-06-30	16497458
Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes.	2006-01	16235228
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics.	2005-12-19	16307739
Blockade of 5-HT(3) receptor with MDL 72222 and Y 25130 reduces beta-amyloid protein (25--35)-induced neurotoxicity in cultured rat cortical neurons.	2005-09-27	16150439
Chronic stimulation of GABAA receptor with muscimol reduces amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical cells.	2005-08	15896866
Stimulation of 5-HT1A receptor with 8-OH-DPAT inhibits hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells.	2005-03	15661577
The effect of tryptophan depletion on the action of haloperidol in MK-801-treated rats.	2004-10-11	15464096
Time-dependent changes in CRH concentrations and release in discrete brain regions following global ischemia: effects of MK-801 pretreatment.	2004-07-30	15234251
GABA(A) and GABA(C) receptor antagonists increase retinal cyclic GMP levels through nitric oxide synthase.	2004-04-20	15088716
MK-801- and ethanol-induced activity in inbred long-sleep and short-sleep mice: dopamine and serotonin systems.	2002-12-20	12464358
Protection against glutamate toxicity through inhibition of the p44/42 mitogen-activated protein kinase pathway in neuronally differentiated P19 cells.	2001-08-01	11434901
A metabotropic glutamate receptor antagonist, alpha-methyl-4-carboxyphenylglycine, attenuates immediate early gene mRNA expression following traumatic injury in cultured rat cortical glial cells.	2001-06-22	11403968
Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats.	2001-06-08	11376890
Blockade of AMPA/kainate receptors can either decrease or increase the survival of cultured neocortical cells depending on the stage of maturation.	2001-05	11248399
The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures.	2001-04-13	11292452
Selective blockade of the mGluR1 receptor reduces traumatic neuronal injury in vitro and improvesoOutcome after brain trauma.	2001-02	11161632
On the mechanisms of neuroprotection by creatine and phosphocreatine.	2001-01	11208905

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:37:19 GMT 2025` Edited by `admin` on `Mon Mar 31 22:37:19 GMT 2025`
Record UNII	2V2JET5YTL
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DIZOCILPINE (-)-FORM [MI]

Preferred Name

English

DIZOCILPINE, (-)-

Common Name

English

5H-DIBENZO(A,D)CYCLOHEPTEN-5,10-IMINE, 10,11-DIHYDRO-5-METHYL-, (5R,10S)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

6337640