BAZLITORAN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Mon Mar 31 23:17:57 GMT 2025` Edited by `admin` on `Mon Mar 31 23:17:57 GMT 2025`
Sequence Type	OLIGONUCLEOTIDE
Record UNII	2U46M95B5M
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

bazlitoran [INN]

Preferred Name

English

BAZLITORAN

Official Name

English

ALL-P-AMBO-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOADENYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-DEOXY-P-THIOCYTIDYLYL-(3'->5')-P-THIOTHYMIDYLYL-(3'->5')-2'-O-METHYL-P-THIOGUANYLYL-(3'->5')-2'-O-METHYL-P-THIOURIDYLYL-(

Systematic Name

English

Bazlitoran [WHO-DD]

Common Name

English

BAZLITORAN [USAN]

Common Name

English

DNA, D(P-THIO)(C-T-A-T-C-T-RGM-RUM-M5C-C7G-T-T-C-T-C-T-RGM-RUM)

Systematic Name

English

IMO-8400

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

417813

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

Code System Code Type Description

PUBCHEM

119058029

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

USAN

EF-108

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

FDA UNII

2U46M95B5M

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

NCI_THESAURUS

C114975

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

CAS

1378549-07-5

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

INN

10184

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

DRUG BANK

DB14990

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

SMS_ID

300000034068

Created by admin on Mon Mar 31 23:17:57 GMT 2025 , Edited by admin on Mon Mar 31 23:17:57 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_1-1_6;1_9-1_16	14 / 18
2'-O-Methyl-Ribose	1_7-1_8;1_17-1_18	4 / 18

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					1NLR4WAG4U

BAZLITORAN SODIUM

SALT/SOLVATE -> PARENT


					3PDA6T8Q7J

TOLL-LIKE RECEPTOR 8

TARGET -> INHIBITOR


					7GAF379J5J

TOLL-LIKE RECEPTOR 9

TARGET -> INHIBITOR

1873203CCC

TOLL-LIKE RECEPTOR 7

TARGET -> INHIBITOR

Related Record Type Details


					2U46M95B5M

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE_SUBSTITUTION	[1_10]		GUANINE	Amount:	7-DEAZA-2'-DEOXYGUANOSINE	7668FG8W4U
NUCLEOSIDE_SUBSTITUTION	[1_9]	SITE_SPECIFIC	CYTOSINE		5-METHYLDEOXYCYTIDINE	B200GV71QM

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:CALCULATED	CHEMICAL