Sabirnetug

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:06:03 GMT 2025` Edited by `admin` on `Wed Apr 02 09:06:03 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2
Sequence Origin	MOUSE CHIMERIC
Sequence Type	COMPLETE
Record UNII	2U1A25MKP9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACU-193

Preferred Name

English

Sabirnetug

Official Name

English

sabirnetug [INN]

Common Name

English

immunoglobulin G2-kappa, anti-[Homo sapiens APP (amyloid beta A4 precursor protein) Abeta42 and Abeta40 soluble non-fibrillar oligomers], humanized monoclonal antibody; gamma2 heavy chain humanized (1-443) [VH (Homo sapiens IGHV3-48*01 (92.9%) -(IGHD) -I

Common Name

English

SABIRNETUG [USAN]

Common Name

English

ACU193

Code

English

Immunoglobulin G2 [264-histidine,305-valine,326-alanine,327-proline], anti-(human A? oligomer) (human-Mus musculus monoclonal ACU193 g2-chain), disulfide with human-Mus musculus monoclonal ACU193 k-chain, dimer

Common Name

English

Code System Code Type Description

FDA UNII

2U1A25MKP9

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

CAS

2747959-38-0

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

INN

12509

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

NCI_THESAURUS

C199109

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

SMS_ID

300000051793

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

USAN

MN-33

Created by admin on Wed Apr 02 09:06:03 GMT 2025 , Edited by admin on Wed Apr 02 09:06:03 GMT 2025

PRIMARY

From	To
4_139	4_199
4_23	4_93
3_139	3_199
3_23	3_93
2_131	4_219
1_131	3_219
2_363	2_421
2_257	2_317
2_144	2_200
2_22	2_96
1_363	1_421
1_257	1_317
1_226	2_226
1_223	2_223
1_220	2_220
1_219	2_219
1_144	1_200
1_22	1_96

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					2U1A25MKP9

ACTIVE MOIETY

Comments:

selectively targets soluble beta-amyloid oligomers

Interaction Type:

IN-VIVO

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_443] [2_443]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL