KN-93

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H29ClN2O4S
Molecular Weight	501.037
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(C=C1)S(=O)(=O)N(CCO)C2=CC=CC=C2CN(C)C\C=C\C3=CC=C(Cl)C=C3

InChI

InChIKey=LLLQTDSSHZREGW-AATRIKPKSA-N

InChI=1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+

HIDE SMILES / InChI

Molecular Formula	C26H29ClN2O4S
Molecular Weight	501.037
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Potency
CaM kinase II 2 Target ID: CHEMBL2097164 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8519682	Inhibitor 8504	1.0 µM [IC50]
Voltage-gated potassium channel subunit Kv1.5 43 Target ID: CHEMBL4306 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16368898	Blocker 555	307.0 nM [IC50]
CaM kinase II 2 Target ID: CHEMBL2097164 Sources: https://www.ncbi.nlm.nih.gov/pubmed/26463508	Inhibitor 8504
Inward-rectifier potassium channels 1 Target ID: Inward-rectifier potassium channels Sources: https://www.ncbi.nlm.nih.gov/pubmed/26463508	Inhibitor 8504	102.6 nM [IC50]

PubMed

Title	Date	PubMed
KN-93 inhibits IKr in mammalian cardiomyocytes.	2015-12	26463508
Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner.	2015-07-01	26024774
KN-93, A CaMKII inhibitor, suppresses ventricular arrhythmia induced by LQT2 without decreasing TDR.	2013-10	24142712

Substance Class	Chemical Created by `admin` on `Mon Mar 31 22:36:37 GMT 2025` Edited by `admin` on `Mon Mar 31 22:36:37 GMT 2025`
Record UNII	2TW744QBU1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

KN-93

Code

English

2-(N-(2-HYDROXYETHYL))-N-(4-METHOXYBENZENESULFONYL))AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE

Preferred Name

English

N-(2-(((3-(4-CHLOROPHENYL)-2-PROPEN-1-YL)METHYLAMINO)METHYL)PHENYL)-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULFONAMIDE

Systematic Name

English

BENZENESULFONAMIDE, N-(2-(((3-(4-CHLOROPHENYL)-2-PROPEN-1-YL)METHYLAMINO)METHYL)PHENYL)-N-(2-HYDROXYETHYL)-4-METHOXY-

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/17/1915