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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H34N2O5
Molecular Weight 430.5372
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RAMIPRIL ISOPROPYL ESTER

SMILES

CC(C)OC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(O)=O

InChI

InChIKey=WJWHJJCWHNPKTH-MQBSTWLZSA-N
InChI=1S/C24H34N2O5/c1-15(2)31-24(30)19(13-12-17-8-5-4-6-9-17)25-16(3)22(27)26-20-11-7-10-18(20)14-21(26)23(28)29/h4-6,8-9,15-16,18-21,25H,7,10-14H2,1-3H3,(H,28,29)/t16-,18-,19-,20-,21-/m0/s1

HIDE SMILES / InChI
Molecular Formula C24H34N2O5
Molecular Weight 430.5372
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 5 / 5
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Ramipril isopropyl ester is the proline-containing impurity of ramipril, labelled as ramipril Impurity B. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor, used to treat high blood pressure (hypertension) and congestive heart failure.

Approval Year

Unknown
149124
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Quality by design approach: application of artificial intelligence techniques of tablets manufactured by direct compression.
2012-12
Development of a capillary electrophoresis method for the assay of ramipril and its impurities: an issue of cis-trans isomerization.
2011-05-06
Development and validation of a liquid chromatographic method for the determination of the related substances of ramipril in Altace capsules.
2000-09
Patents

Patents

US20070232680
5

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 22:06:51 GMT 2025
Edited
by admin
on Mon Mar 31 22:06:51 GMT 2025
Record UNII
2S4N8A063C
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RAMIPRIL RELATED COMPOUND B
USP   USP-RS  
Preferred Name English
RAMIPRIL ISOPROPYL ESTER
Common Name English
(2S,3AS,6AS)-1-((2S)-2-(((1S)-1-((1-METHYLETHOXY)CARBONYL)-3-PHENYLPROPYL)AMINO)PROPANOYL)OCTAHYDROCYCLOPENTA(B)PYRROLE-2-CARBOXYLIC ACID
Systematic Name English
RAMIPRIL RELATED COMPOUND B [USP-RS]
Common Name English
CYCLOPENTA(B)PYRROLE-2(2H)-CARBOXYLIC ACID, HEXAHYDRO-1-((2S)-2-(((1S)-1-((1-METHYLETHOXY)CARBONYL)-3-PHENYLPROPYL)AMINO)-1-OXOPROPYL)-, (2S,3AS,6AS)-
Systematic Name English
RAMIPRIL IMPURITY B [EP IMPURITY]
Common Name English
RAMIPRIL RELATED COMPOUND B [USP IMPURITY]
Common Name English
Code System Code Type Description
PUBCHEM
11669166
Created by admin on Mon Mar 31 22:06:51 GMT 2025 , Edited by admin on Mon Mar 31 22:06:51 GMT 2025
PRIMARY
CAS
295328-72-2
Created by admin on Mon Mar 31 22:06:51 GMT 2025 , Edited by admin on Mon Mar 31 22:06:51 GMT 2025
PRIMARY
RS_ITEM_NUM
1598323
Created by admin on Mon Mar 31 22:06:51 GMT 2025 , Edited by admin on Mon Mar 31 22:06:51 GMT 2025
PRIMARY
FDA UNII
2S4N8A063C
Created by admin on Mon Mar 31 22:06:51 GMT 2025 , Edited by admin on Mon Mar 31 22:06:51 GMT 2025
PRIMARY
Related Record Type Details
Structure of RAMIPRIL
PARENT -> IMPURITY
NIH
NCATS
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