Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C45H60Cl2O6 |
| Molecular Weight | 767.86 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@@H](CCC=C(C5=CC(C(O)=O)=C(O)C(Cl)=C5)C6=CC(C(O)=O)=C(O)C(Cl)=C6)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
InChIKey=VOJOOGPALCATLT-ZFQBPCNVSA-N
InChI=1S/C45H60Cl2O6/c1-25(2)8-6-9-26(3)35-14-15-36-32-13-12-30-20-27(16-18-44(30,4)37(32)17-19-45(35,36)5)10-7-11-31(28-21-33(42(50)51)40(48)38(46)23-28)29-22-34(43(52)53)41(49)39(47)24-29/h11,21-27,30,32,35-37,48-49H,6-10,12-20H2,1-5H3,(H,50,51)(H,52,53)/t26-,27+,30+,32+,35-,36+,37+,44+,45-/m1/s1
| Molecular Formula | C45H60Cl2O6 |
| Molecular Weight | 767.86 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 9 / 9 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores. | 2001-03-01 |
|
| Inhibition of RANTES/CCR1-mediated chemotaxis by cosalane and related compounds. | 2001-01-08 |
|
| Anti-HIV activity of a series of cosalane amino acid conjugates. | 2000-11-20 |
|
| Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates. | 2000-09-18 |
|
| Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain. | 2000-01 |
|
| Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency. | 1999-05-20 |
|
| Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent. | 1998-04-07 |
|
| Exploration of the effects of linker chain modifications on anti-HIV activities in a series of cosalane analogues. | 1996-10 |
|
| Correlation of anti-HIV potency with lipophilicity in a series of cosalane analogs having normal alkenyl and phosphodiester chains as cholestane replacements. | 1996-01-19 |
|
| Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase. | 1995-02-03 |
|
| Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. | 1994-09-16 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 19:07:50 GMT 2025
by
admin
on
Mon Mar 31 19:07:50 GMT 2025
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| Record UNII |
2R84Y6217J
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID00165567
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658586
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