TAMITINOL DIHYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H18N2OS.2ClH
Molecular Weight	299.26
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.Cl.CCNCC1=C(O)C(C)=NC=C1CSC

InChI

InChIKey=TYNOKGPWHONZDV-UHFFFAOYSA-N

InChI=1S/C11H18N2OS.2ClH/c1-4-12-6-10-9(7-15-3)5-13-8(2)11(10)14;;/h5,12,14H,4,6-7H2,1-3H3;2*1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C11H18N2OS
Molecular Weight	226.338
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6371575 | Elks J., The Dictionary of Drugs: Chemical Data: Chemical Data, Structures, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ&pg=PA1148&lpg=PA1148&dq=TAMITINOL&source=bl&ots=6JUgp3WAqz&sig=ACfU3U31pJsSiUAAamZPEME_POZP1pBbsQ&hl=ru&sa=X&ved=2ahUKEwiM6pObiJvjAhUiyaYKHdXXCAY4HhDoATAEegQICRAB#v=onepage&q=TAMITINOL&f=false

Tamitinol (also known as EMD 21657), a neurotropic drug that was developed as a cognition enhancer for the treatment of diffuse cerebral disease and organic brain syndrome. Tamitinol participated in clinical trials where the therapeutic effects of the drug were shown to be statistically significant compared to placebo in the global response. However, the treatment was interrupted because of side effects (increased aggressiveness, rash) in 2 cases.

Approval Year

PubMed

Title	Date	PubMed
Tamitinol in paedopsychiatric out-patient therapy.	1981	7323108
Treatment of the organic brain syndrome in the elderly. A double-blind comparison on the effects of a neurotropic drug and placebo.	1983	6371575
Protection of cell proteins against free-radical attack by nootropic drugs: scavenger effect of pyritinol confirmed by electron spin resonance spectroscopy.	1989 Jun	2547179

Sample Use Guides

In Vivo Use Guide

Patients were randomly assigned to two treatment groups of 50 patients each and received either a neurotropic drug (3 X 200 mg EMD 21657 (Tamitinol)) or placebo coated tablets of identical appearance

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:06:30 GMT 2023` Edited by `admin` on `Fri Dec 15 15:06:30 GMT 2023`
Record UNII	2P1SGU7HI0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TAMITINOL DIHYDROCHLORIDE

Common Name

English

4-((ETHYLAMINO)METHYL)-2-METHYL-5-((METHYLTHIO)METHYL)-3-PYRIDINOL DIHYDROCHLORIDE

Systematic Name

English

3-PYRIDINOL, 4-((ETHYLAMINO)METHYL)-2-METHYL-5-((METHYLTHIO)METHYL)-, DIHYDROCHLORIDE

Common Name

English

3-PYRIDINOL, 4-((ETHYLAMINO)METHYL)-2-METHYL-5-((METHYLTHIO)METHYL)-, HYDROCHLORIDE (1:2)

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

261-789-7