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VOLANESORSEN
2O4BE0K238
Investigational
General
Record Details
Names
8
Classification
3
Identifiers
11
Subunits
1
Sugars
2
Linkages
1
Relationships
1
Active Moiety
1
Modifications
2
VOLANESORSEN
2O4BE0K238
Investigational
General
Approval Year
Unknown
139,594
Record Details
Substance Class
Nucleic Acid
Nucleic Acid Subtype
Sequence Type
P0LYNUCLEOTIDE
Record UNII
2O4BE0K238
Record Status
Validated (UNII)
Record Version
20
19
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16
15
14
13
12
11
10
9
8
7
6
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4
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2
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Names
8
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entries
Name
Type
Language
Name
Type
Language
VOLANESORSEN
Official Name
English
ISIS 304801 FREE ACID
Code
English
ISIS-304801
Code
English
volanesorsen [INN]
Common Name
English
ISIS 304801
Common Name
English
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Classification
3
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Classification Tree
Code System
Code
Classification Tree
Code System
Code
Agent Affecting Digestive System or Metabolism
Pharmacologic Substance
[C1909]
Agent Affecting Digestive System or Metabolism
[C78276]
Antilipidemic Agent
NCI_THESAURUS
C29703
Gene Therapy Agent
Pharmacologic Substance
[C1909]
Biological Agent
[C307]
Gene Therapy Agent
[C1962]
Antisense Oligonucleotides
NCI_THESAURUS
C1291
Designated
ORPHAN DRUG
Designated
treatment of familial chylomicronemia syndrome
FDA ORPHAN DRUG
480815
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Identifiers
11
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Code System
Code
Type
Description
Code System
Code
Type
Description
DRUG BANK
DB15067
PRIMARY
FDA UNII
2O4BE0K238
PRIMARY
DRUG CENTRAL
5335
PRIMARY
ChEMBL
CHEMBL3544994
PRIMARY
CAS
915430-78-3
PRIMARY
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Subunits
1
Sugars
2
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Sugar
Site Range
Site Count
Sugar
Site Range
Site Count
2'-O-Methoxyethyl ribose
1_1-1_5;1_16-1_20
10 / 20
Deoxyribose (DNA)
1_6-1_15
10 / 20
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Linkages
1
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entries
Linkage
Site Range
Site Count
Linkage
Site Range
Site Count
Phosporothioate
1_2-1_20
19 / 19
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Relationships
1
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Related Record
Type
Details
Related Record
Type
Details
6JON30SLDT
VOLANESORSEN SODIUM
SALT/SOLVATE -> PARENT
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Active Moiety
1
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Related Record
Type
Details
Related Record
Type
Details
2O4BE0K238
VOLANESORSEN
ACTIVE MOIETY
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Modifications
2
Structural Modifications
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Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
Modification Type
Location Site
Location Type
Residue Modified
Extent
Fragment Name
Fragment Approval
NUCLEOSIDE SUBSTITUTION
[1_3]
C
2'-O-(2-METHOXYETHYL)-5-METHYLCYTIDINE
AOQ54IZZ6J
NUCLEOSIDE SUBSTITUTION
[1_6] [1_11] [1_12] [1_15]
C
5-METHYLDEOXYCYTIDINE
B200GV71QM
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