Stereochemistry | ABSOLUTE |
Molecular Formula | C25H32O13 |
Molecular Weight | 540.5138 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]2(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C([C@@H](CC(=O)OCCC3=CC(O)=C(O)C=C3)\C2=C/C)C(=O)OC
InChI
InChIKey=RFWGABANNQMHMZ-ZCHJGGQASA-N
InChI=1S/C25H32O13/c1-3-13-14(9-19(29)35-7-6-12-4-5-16(27)17(28)8-12)15(23(33)34-2)11-36-24(13)38-25-22(32)21(31)20(30)18(10-26)37-25/h3-5,8,11,14,18,20-22,24-28,30-32H,6-7,9-10H2,1-2H3/b13-3+/t14-,18+,20+,21-,22+,24-,25-/m0/s1
Molecular Formula | C25H32O13 |
Molecular Weight | 540.5138 |
Charge | 0 |
Count |
MOL RATIO
1 MOL RATIO (average) |
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 7 / 7 |
E/Z Centers | 1 |
Optical Activity | UNSPECIFIED |
Oleuropein is a phenylethanoid, a type of phenolic compound found in olive leaf together with other closely related compounds such as 10-hydroxyoleuropein, ligstroside, and 10-hydroxyligstroside. Oleuropein is traditionally removed from olives due to its bitterness. In preliminary laboratory research, oleuropein had activity as an agonist of the G-protein estrogen receptor. Oleuropein inhibited the enzymatic activity of mammalian target of rapamycin (mTOR), suggesting that mTOR inhibition is at least one of the reasons for the reported anti-cancer properties of oleuropein.
Originator
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
PubMed
Patents
Sample Use Guides
he effects of oleuropein was examined in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) and four coronary ligated groups assigned to receive vehicle or oleuropein at 5, 10, or 20 mg/kg/day. Five weeks later, echocardiographic and hemodynamic parameters, serum concentrations of oxidative stress, and inflammatory markers were determined.
Route of Administration:
Oral
The minimum inhibitory concentration (expressed as MIC 90%) of oleuropein against C. Albicans ATCC 10231 was assessed using serial broth microdilution of oleuropein in RPMI 1640% + 2% glucose (w/v) from 25 mg/mL to 12.21 mkg/mL. Minimal inhibitory concentration (MIC) of oleuropein against C. albicans was 12.5 mg/ml