Pacibekitug

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:00:03 GMT 2025` Edited by `admin` on `Tue Apr 01 22:00:03 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG2\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	2NHW9AKY9C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Pacibekitug

Official Name

English

PF-04236921

Preferred Name

English

pacibekitug [INN]

Common Name

English

H-gamma2 heavy chain Homo sapiens (1-442) [VH (Homo sapiens IGHV4-34*12 (95.9%) -(IGHD) -IGHJ3*02 (93.8%), CDR-IMGT [8.7.10] (26-33.51-57.96-105)) (1-116) -Homo sapiens IGHG2*01 (100%), G2m.. CH2 V45.1 (CH1 (117-214), hinge 1-12 (215-226), CH2 V45.1 (277

Common Name

English

Immunoglobulin G2 [24-isoleucine,30-arginine], anti-(human interleukin 6) (human-Mus musculus monoclonal TOUR006 ?2-chain), disulfide with human-Mus musculus monoclonal TOUR006 ?-chain, dimer

Common Name

English

PACIBEKITUG [USAN]

Common Name

English

TOUR006

Code

English

HUMAN ANTI-IL-6 MONOCLONAL ANTIBODY (PF-04236921)

Common Name

English

PF-4236921

Code

English

TOUR-006

Code

English

immunoglobulin G2-kappa, anti-[Homo sapiens IL6 (interleukin 6, IL-6)], Homo sapiens monoclonal antibody

Common Name

English

Code System Code Type Description

SMS_ID

300000038816

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

FDA UNII

2NHW9AKY9C

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

CAS

1822383-06-1

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

NO STRUCTURE GIVEN

NCI_THESAURUS

C206961

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

INN

13060

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

USAN

MN-269

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

CAS

2948444-06-0

Created by admin on Tue Apr 01 22:00:03 GMT 2025 , Edited by admin on Tue Apr 01 22:00:03 GMT 2025

PRIMARY

From	To
1_22	1_95
1_130	3_214
1_143	1_199
1_218	2_218
1_219	2_219
1_222	2_222
1_225	2_225
1_256	1_316
1_362	1_420
2_22	2_95
2_130	4_214
2_143	2_199
2_256	2_316
2_362	2_420
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_292
N	2_292

Related Record Type Details


					4O4QWG0B3C

HUMAN INTERLEUKIN-6

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					2NHW9AKY9C

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_442] [2_442]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL