Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C17H28N2O2.ClH |
| Molecular Weight | 328.877 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.CCCCN(CCCC)C(C(N)=O)C1=CC=C(OC)C=C1
InChI
InChIKey=FZOGOYCDAVNSFE-UHFFFAOYSA-N
InChI=1S/C17H28N2O2.ClH/c1-4-6-12-19(13-7-5-2)16(17(18)20)14-8-10-15(21-3)11-9-14;/h8-11,16H,4-7,12-13H2,1-3H3,(H2,18,20);1H
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C17H28N2O2 |
| Molecular Weight | 292.4164 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies with a uterine antispasmodic, ambucetamide. | 1957 Sep |
|
| The effects of ambucetamide on human myometrial and other preparations, and its antagonism to the menstrual stimulant. | 1960 Mar |
|
| Rapid spectrophotometric determination of saccharin in soft drinks and pharmaceuticals using Azure B as reagent. | 1983 Aug |
|
| Determination of embutramide in biological matrices by gas chromatography with nitrogen-phosphorus detection. | 1994 Nov 4 |
Patents
Sample Use Guides
Dogs: In general, doses of 1.0 to 10.0 mg/Kg of ambucetamide produced a drop in tone in the majority of the animals and had no effect upon the
frequency of contractions. In about 50% of the dogs there was an increase in the amplitude of contractions at doses of 1.0 and 5.0 mg/Kg, but
at a dose of 10.0 mg/Kg the majority showed a decrease in the amplitude of contractions.
Route of Administration:
Oral
In Vitro Use Guide
Curator's Comment: The effect of ambucetamide on the isolated rat uterus was studied by a modification of the method of Magnus. The isolated uterus was suspended in a Ringer Tyrode solution modified according to Smith and maintained at
37.5.
Ambucetamide produced a decrease in the amplitude
of contraction starting in most instances at a
bath concentration of 0.025 mg/cc. This effect was quite marked at a concentration of 0.05 mg/cc.
It produced a marked decrease in the frequency of
contractions starting with a bath concentration of 0.125 mg/cc. No decrease in tone was noted at concentrations less than 0.025 mg/cc.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:00:15 GMT 2023
by
admin
on
Fri Dec 15 19:00:15 GMT 2023
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| Record UNII |
2M010V3MAJ
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| Record Status |
Validated (UNII)
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| Record Version |
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172343-32-7
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SUB00428MIG
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100000085128
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71587573
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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|
PARENT -> SALT/SOLVATE | |||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |