D&C Red No. 27 are fluorescein-based dyes that were approved in 1982 for use in drugs and cosmetics Cosmetic retail products containing this dye is primarily lipsticks and blushers. D&C Red No. 27 physically associated with non-aqueous aluminum or zirconium minerals (lakes) and used in lipsticks, blushers, make-up preparations, hair dyes and colors, rouges and face powders. The FDA lists D&C Red No. 27 as a safe additive for drugs and cosmetics as per FDA standards.