GR-127935

Details

Stereochemistry	ACHIRAL
Molecular Formula	C29H31N5O3
Molecular Weight	497.5881
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC=C(NC(=O)C2=CC=C(C=C2)C3=CC=C(C=C3C)C4=NOC(C)=N4)C=C1N5CCN(C)CC5

InChI

InChIKey=YDBCEBYHYKAFRX-UHFFFAOYSA-N

InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)

HIDE SMILES / InChI

Molecular Formula	C29H31N5O3
Molecular Weight	497.5881
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Potency
5-hydroxytryptamine receptor 1D 18	Antagonist 2,849	8.5 null [pKi]
Serotonin 1b (5-HT1b) receptor 45	Antagonist 2,849	8.5 null [pKi]
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1	Antagonist 2,849	6.4 null [pKi]
Serotonin 1a (5-HT1a) receptor 177	Binding Agent 1,076	6.5 null [pKi]
Serotonin 1 receptors; 5-HT1B & 5-HT1D 4	Antagonist 2,849	141.0 nM [EC50]

PubMed

Show entries

Title	Date	PubMed
Potentiation of fluoxetine-induced penile erections by combined blockade of 5-HT1A and 5-HT1B receptors.	1997 Mar 5	9085055
The selective 5-HT1B receptor inverse agonist 1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2, 4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro- spiro[furo[2,3-f]indole-3,4'-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo.	1998 Apr 9	9548813
SB-224289--a novel selective (human) 5-HT1B receptor antagonist with negative intrinsic activity.	1998 Sep	9776361
Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats.	2001 Apr	11396515
A61603-induced vasoconstriction in porcine carotid vasculature: involvement of a non-adrenergic mechanism.	2001 Apr 13	11334851

Showing 1 to 5 of 8 entries

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Patents

Substance Class	Chemical
Record UNII	2LLH6CEB40
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

(1,1'-BIPHENYL)-4-CARBOXAMIDE, N-(4-METHOXY-3-(4-METHYL-1-PIPERAZINYL)PHENYL)-2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)-

Preferred Name

English

GR-127935

Common Name

English

Showing 1 to 2 of 2 entries

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Show entries

Code System

Code

Type

Description

CHEBI

64114

PRIMARY

PUBCHEM

107780

PRIMARY

FDA UNII

2LLH6CEB40

PRIMARY

CAS

148672-13-3

PRIMARY

WIKIPEDIA

GR-127935

PRIMARY

Showing 1 to 5 of 6 entries

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