PIROLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H15N3O5
Molecular Weight	329.3074
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)C1=NC(=O)C2=C(N1)N=C3C=C(OC)C(OC)=CC3=C2

InChI

InChIKey=KIDJDJMACBOHKQ-UHFFFAOYSA-N

InChI=1S/C16H15N3O5/c1-4-24-16(21)14-18-13-9(15(20)19-14)5-8-6-11(22-2)12(23-3)7-10(8)17-13/h5-7H,4H2,1-3H3,(H,17,18,19,20)

HIDE SMILES / InChI

Molecular Formula	C16H15N3O5
Molecular Weight	329.3074
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 998, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf | De Las Heras, F.G., Vega, S. (2016) Medicinal Chemistry Advances, page 336, retrieved from: https://books.google.ru/books?id=hdT9BAAAQBAJ | Buckle, D.R., Smith, H. (2013) Development of Anti-Asthma Drugs, page 280, retrieved from: https://books.google.ru/books?id=owklBQAAQBAJ

Pirolate is the pyrimidoquinoline. It was developed as an antiasthmatic and antiallergic agent. Pirolate does show high potency in passive cutaneous anaphylaxis in rats, both by intravenous and oral routes. It has some 84 times the potency of disodium cromoglycate. Pirolate is a leukotriene biosynthesis inhibitor.

Approval Year

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:49:08 GMT 2025` Edited by `admin` on `Mon Mar 31 18:49:08 GMT 2025`
Record UNII	2LF7L6QD58
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CP-32,387

Preferred Name

English

PIROLATE

Official Name

English

PIROLATE [USAN]

Common Name

English

CP-32387

Code

English

PYRIMIDO(4,5-B)QUINOLINE-2-CARBOXYLIC ACID, 1,4-DIHYDRO-7,8-DIMETHOXY-4-OXO-, ETHYL ESTER

Common Name

English

NSC-355079

Code

English

pirolate [INN]

Common Name

English

Ethyl 1,4-dihydro-7,8-dimethoxy-4-oxopyrimido[4,5-b]quinoline-2-carboxylate

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29712