ENEFEXINE

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H19N
Molecular Weight	189.2967
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC1=CC=C(C=C1)C2CCNCC2

InChI

InChIKey=NDPOGPAZKKPOPV-UHFFFAOYSA-N

InChI=1S/C13H19N/c1-2-11-3-5-12(6-4-11)13-7-9-14-10-8-13/h3-6,13-14H,2,7-10H2,1H3

HIDE SMILES / InChI

Molecular Formula	C13H19N
Molecular Weight	189.2967
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.google.ru/patents/US8729070 | https://www.google.com/patents/US6096742 | http://www.google.com.na/patents/CA2644662A1

ENEFEXINE is a pharmaceutical drug derived from 4-phenylpiperdine, it is CNS active agent, an antidepressant.

CNS Activity

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 240 Sources: https://www.google.ru/patents/US8729070 https://www.google.com/patents/US6096742 http://www.google.com.na/patents/CA2644662A1	Primary		Approved 8583	Unknown Approved Use Unknown

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
CYP2C19 2057 CYP1A2 2153

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 62.0	no
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 62.0	no
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 58.0	no
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 56.0	no
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 1.0	yes [IC50 0.3467 uM]

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/compound/208916#section=Biological-Test-Results Page: 61.0

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 07:40:12 GMT 2025` Edited by `admin` on `Wed Apr 02 07:40:12 GMT 2025`
Record UNII	2JMM46GA2V
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

ENEFEXINE

Official Name

English

4-(P-ETHYLPHENYL)PIPERIDINE

Preferred Name

English

enefexine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265